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International Journal of Nutrology
Articles
DOI: 10.1055/s-0040-1705275
Submitted: 02-06-2022
Published: 02-06-2022

Micronutrientes e Diminuição do Estresse Oxidativo nos Espermatozoides

Médico Pós-Graduando em Nutrologia pela ABRAN
Antioxidants Oxidative Stress Male Infertility Micronutrients

Abstract

The integrity of spermatozoa in the seminal fluid given its parameters (motility, concentration, morphology and vitality) is important for the reproductive function. The oxidative stress can adversely affect the quality of the semen, which causes the damage and dysfunction of the sperm. Thus, a literature review based on Pubmed was held seeking studies that aimed to improve the quality of sperm with the use of antioxidants. The use of certain vitamins and minerals seem to affect the sperm quality. Literature data on single or combined oral use of these micronutrients in improving semen parameters and fertility potential are limited and scarce. Thus, it is essential to develop new studies that enable micronutrient dosages settings, as well as their combinations in improving sperm quality. The use of oral antioxidants has proved to be a promising strategy for a non-invasive treatment that reduces the need to use assisted reproductive technologies; providing lower costs in the management of male infertility.

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References

  1. JUUL, S.; KARMAUS, W.; OLSEN, J. Regional differences in waiting time to pregnancy: pregnancy-based surveys from Denmark, France, Germany, Italy and Sweden. Hum. Reprod., v.14, n.5, p.1250-1254, 1999.
  2. ZHU, J.L. et al. Infertility, infertility treatment and psychomotor development: the Danish National Birth Cohort. Paediatr. Perinat. Epidemiol., v.23, p.98-106, 2009.
  3. World Health Organization (WHO). Infecundity, infertility, and childlessness in developing countries. Demographic and Health Surveys (DHS) Comparative reports n. 9. Calverton, Maryland, USA, 2000.
  4. MAIA, F. A. Avaliação dos parâmetros seminais de indivíduos inférteis em uso de polivitamínico e polimeneral. 2009. 86f. Dissertação (Mestrado em Ginecologia, obstetrícia e mastologia). Faculdade de Mediciana de Botucatu, Universidade Estadual Paulista. São Paulo.
  5. CHAKRABORTY, Santanu. The roleof Na, K-ATPase alpha isoforms and Na/H exchangers in sperm motility. Doctor Degree, Miami University. Ohio, 2006.
  6. MS – Ministério da Saúde. Portal da Saúde. Reprodução Humana Assistida. 2005.
  7. MAKUCH, M.Y. et al. Inequitableaccess to assisted reproductive technology for the low-income Brazilian population: a qualitative study. Human Reproduction. V.26, n.8, p.2054-60, 2011.
  8. GUILLETTE, J.R.L.J.; CRAIN, D.A. Environmental Endocrine Disrupters: an EvolutionaryPerspective. Taylor & Francis Ed. United States of America, 2000.
  9. SKAKKEBAEK, N.E.; GIWERCMAN, A. The human testis – an organ at risk? Int J Androl. 1992; 15 (5):373-5.
  10. SANTAMARTA, J. Por um futuro sem contaminantes orgânicos persistentes. Agroecologia e Desenvolvimento Rural Sustentável 2001; 2:46-56.
  11. SKAKKEBAEK, N.E. et al. Testicular dysgenesis syndrome: an increasing common developmental disorder with environmental aspects. Hum Reprod 2001; 16:972-8.
  12. SIKKA,S.C.; RAJASEKARAN.M.; HELLSTROM, W.J.G. Role of oxidative stress and antioxidants in male infertility. Journal of Andrology, 1995; 16(6), p. 464-468.
  13. DESAI, N.R.; MAHFOUZ, R.; SHARMA, R.; GUPTA, S.; AGARWAL, A. Reactive oxygen species levels are independent of sperm concentration, motility, and abstinence in a normal, healthy, proven fertileman: a longitudinal study. Fertil. Steril., 2010; 94(4), p. 1541-1543.
  14. TREMELLEN, K. Oxidative stress and male infertility – a clinical perspective. Human Reproduction Update, 2008; 14(3), p. 243–258.
  15. AGARWAL, A.; PRABAKARAN. S.A.; SAID, T. M. Prevention of Oxidative Stress Injury to Sperm. Journal of Andrology. V.26, n.6, p.654-60, 2005.
  16. AGARWAL, A; MAKKER, K; SHARMA, R. Clinical Relevance of Oxidative Stress in Male Factor Infertility: Na Update. American Journal of Reproductive Imunology, v.59, n.1, p.2-11, 2008.
  17. SCHIMID, E.T. et al. Micronutients intake is associated with Improved sperm DNA quality in older men. Fertility and Sterility, v.98, n. 5/November 2012.
  18. EBISH, I.M., W. et al. The importance of folate, zinc e antioxidants in pathogenesis and prevention of subfertility. Human Reproduction, v. 13, n.2, p.163-74, 2007.
  19. BROWN, A.E. Pesticides and the Endocrine System. Pesticide Information Leaflet Series 1999; 34: 1-5.
  20. AITKEN, R.J. Leukocytospermia, oxidative stress and sperm function. In: Hellstrom WJG ed. Male infertility and sexual dysfunction. New York: Springer-Verlag; 1997.
  21. HAKIN, L.S.; OATES, R.D. Nonsurgical treatment of male infertility: Specific Therapy. In: Infertility in the Male. St. Louis: Lipshultz LI & Howards SS; 1997.
  22. World Health Organization (WHO). WHO Laboratory Manual for the examination of spermatozoa and sperm-cervical mucus interaction. New York: Cambridge University Press; 1999.
  23. WONG, W. Y. et al. Effects of folic acid and zinc sulfate on male fator subfertility: a double-blind, placebo-controlled trial. Fertility and Seterility, v.77, n.3, p.491-98, 2002.
  24. GONZAGA, I.B.; MARTENS, A.; COZZOLINO, S.M.F. Selênio. In: COZZOLINO, S.M.F., org. Biodisponibilidade de nutrientes. 2. ed. Barueri: Manole,2007. Cap.28, p.575-613.
  25. VERNET, P.; AIKEN, R.J.; DREVET, J.R. Antioxidant strategies in the epididymis. Mol Cell Endocrinol, 216, p.31-39, 2004.
  26. MAIORINO, M.; WISSING, J.B..; BRIGELIUS-FLOHÉ, R.; CALABRESE, FIORELLA; ROVERI, A.; STEINERT, P.; URSINI, F.; FLOHÉ, L. Testosterone mediates expression of the selenoprotein PHGPx by induction of spermatogenesis and not by direct transcriptional gene activation. The FASEB Journal, 12, p. 1359-1370, 1998.
  27. FORESTA, C.; FLOHÉ, L.; GAROLLA, A. et al. Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione preoxidase. Biology of Reproduction, 67, p. 967-971, 2002.
  28. BLEAU, G.; LEMARBRE, J.; FAUCHER, G. Semen selenium and human fertility. Fertil Steril. 1984; 42(6):890-94.
  29. HANSEN, J.C.; DEGUCHI, Y. Selenium and fertility in animals and man – a review. Acta Vet Scand. 1996; 37(1):19-30.
  30. IWANIER, K.; ZACHARA, B.A. Selenium supplementation enhances the element concentration in blood and seminal fluid but does not change the spermatozoal quality characteristics in subfertile men. J Androl. 1995; 16(5):441-47
  31. XU, D.; ONG, C.; SHEN, H. The associations between concentration of selenium in semen and sperm parameters as well as oxidative DNA damage in human sperm. Zhonghua Yu Fang Yi Xue Za Zhi. 2001; 35(6):394-96
  32. SCOTT, R.; MACPHERSON, A.; YATES, R.W.S., HUSSAIN, B, DIXON, J. The effect of oral selenium supplementation on human sperm motility. Br J Urol. 1998; 82(1):7680
  33. NIKOLAEV, A.L.; LOZHKINA, LV; et Al. Selenium correction of male subfertility. 1999; (4):29-32.
  34. WONG, W. Y.; THOMAS, C. M. G.; MERKUS, J. M. W. M.; ZIELHUIS, G. A.; STEEGERS-THEUNISSEN, R. P. M. Male factor subfertility: possible causes and the impact of nutritional factors. Fertility and Sterility, 73, p. 435-442, 2000.
  35. YUYAMA, L.K.O.; MARINHO, H.A.; ALENCAR, F. H.; COZZOLINO, S.M.F. Vitamina A (retinol) e carotenóides. In: COZZOLINO, S.M.F. Biodisponibilidade de nutrientes. Barueri, SP: Manole, p.219-261, 2007.
  36. YUYAMA, L.K.O.;YONEKURA, L.; AGUIAR, J.P.L.; RODRIGUES, M.L.C.F.; COZZOLINO, S.M.F. Zinco. In: COZZOLINO, S.M.F. Biodisponibilidade de nutrientes. Barueri, SP: Manole, p.549-574, 2007 (A).
  37. CHUNG, S.S.; WOLGEMUTH, D.J. Role of retinoid signaling in the regulation of spermatogenesis. Cytogenet Genome RES., 105, p. 189-202, 2004.
  38. COZZOLINO, S.M.F. Vitamina E (tocoferol) e carotenóides. In: COZZOLINO, S.M.F. Biodisponibilidade de nutrientes. Barueri, SP: Manole, p.276-292, 2007.
  39. AGARWAL, A et al. Role of antioxidants in treatment of male infertility: na overview of the literature. Reproductive BioMedicine Online. V. 8, n.6, p.616-27, 2004.
  40. LEWIS, S. E.; STERLING, E. S.; YOUNG, I. S. et al. Comparison of individual antioxidants of sperm and seminal plasma in fertile and infertile men. Fertility and Sterility, 67, p. 142147, 1997.
  41. JOSHI, R.; ADHIKARI, S.; PATRO, B. S.; CHATTOPADHYAY, S.; MUKHERJEE, T. Free radical scavenging behavior of folic acid: evidence for possible antioxidant activity. Free Radic Biol Med, 30, p. 1390-1399, 2001.
  42. BAYNES J.W.; DOMINICZAK, M. H. Bioquímica médica. 2. ed. Rio de Janeiro: Elsevier, 2007.
  43. MAFRA, D.; COZZOLINO, S.M.F. Ácido fólico. In: COZZOLINO, S.M.F. Biodisponibilidade de nutrientes. Barueri, SP: Manole, p.385-399, 2007.
  44. KODAMA, H.; TAMAGUCHI, R.; FUKUDA, J. et al. Increased oxidative deoxiribonucleic acid damage in the spermatozoa of infertile male patients. Fertility and Sterility, 68, p. 519-524, 1997.
  45. COMHAIRE, F. H.; CHRISTOPHE, A. B.; ZALATA, A. A.; DHOOGE, W.S.; MAHMOUD, A.M.A.; DEPUYDT, C.E. The effects of combined conventional treatment, oral antioxidants and essential fatty acids on sperm biology in subfertil men. Prostaglandins Leucotrienes and essential Fatty Acids, 63, p. 159-165, 2000.
  46. SULEIMAN, S. A.; ALI, M. E.; ZAKI, Z. M. et al. Lipid peroxidation and human sperm motility: proctectiv role of vitamin E. Journal of Andrology, 17, p. 530-537, 1996.
  47. SCOTT, R.; MACPHERSON, A.; YATES, R. W. et al. The effect of oral selenium suplementation on human sperm motility. British Journal of Urology, 82, p. 76-80, 1998.
  48. KESKES-AMMAR, L.; FEKI-CHAKROUN, N.; REBAI, T. et al. Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertility men. Archives of Andrology, 49, p. 83-94, 2003.
  49. TIKKIWAL, M.; AJMERA, R. L.; MATHUR, N. K. Effect of zinc administration on seminal zinc and fertility of oligospermic males. Ondian J Physiol Pharmacol, 31, p. 30- 34, 1987.
  50. OMU, A. E.; DASHTI, H.; AL-OTHMAN, S. Treatment of asthenozoospermia with zinc sulfate: andrological, immunological and obstetric outcome. European Journal Obstetrics & Gynecology and Reproductive Biology, 79, p. 179-184, 1998.
  51. VEZINA, D.; MAUFFETTE, F.; ROBERTS, K. D. et al. Selenium-vitamin E suplementation in infertile men. Effects on semen parameters and micronutrient levels and distribution. Biological Trace Element Research, 53, p. 65-83, 1996.
  52. KESSOPOULOU, E.; POWERS, H. J.; SHARMA, K. K. et al. A double-blind randomized placebo crossover controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertility and Sterility, 64, p. 825-831, 1995.
  53. MOILANEN, J.; HOVATTA, O. Excretion of alpha-tocopherol intro human seminal plasma after oral administration. Andrologia, 27, p. 133-136, 1995.
  54. IWANIER, K.; ZACHARA, B. A. Selenium supplementation enhances the element concentration in blood and seminal fluid but does not change the spermatozoal quality characteristics in subfertile men. Journal of Andrology, 16, p. 441-447, 1995.
  55. ROLF, C.; COOPER, T. G.; YEUNG, C. H. et al. Antioxidant treatment of patients with asthenozoospermia or moderate oligoasthenozoospermia with high-dose vitamin C and vitamin E: a randomized, placebo-controlled, double-blind study. Human Reproduction, 14, p. 1028-1033, 1999.

How to Cite

Ciattei, A. P. (2022). Micronutrientes e Diminuição do Estresse Oxidativo nos Espermatozoides. International Journal of Nutrology, 9(1), 153–159. https://doi.org/10.1055/s-0040-1705275