Skip to main content Skip to main navigation menu Skip to site footer
Articles
Published: 02-23-2022

Doença celíaca e introdução do glúten na dieta infantil: avaliação dos riscos e benefícios

Medico do ICr do HCFMUSP e do H. Albert Einstein SP, Brasil
Gluten Celiac Disease Nutrition

Abstract

Celiac disease (CD) is a systemic disease, immune-mediated, caused by the ingestion of gluten. The risk of induction of celiac disease through infant diet containing gluten, applies solely to genetically susceptible individuals, i.e. those having at least one risk allele for this disease. Given we do not usually know if the child fits this criteria, at the time of introduction of cereal in the baby food, the recommendations regarding the risks and benefits of introduction of gluten in baby’s nutrition applies to all of infants. In 2008, the Committee on Nutrition of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) recommended that the introduction of gluten in the infant diet before 4 months and after 7 months of age should be avoided and that the introduction of gluten should happen during breastfeeding. However, new evidences found by ESPGHAN contradict those previous recommendations. While breastfeeding should be encouraged due to other great benefits, neither breastfeeding nor the introduction of gluten during breastfeeding seems to lower the risk of CD in childhood. Gluten can be introduced in infant diet between 4 and 12 months old. Data from observational studies indicate an association between the quantity of gluten ingested and the risk of celiac disease. Large amounts of gluten consumption should be avoided in the first few weeks, after introduction of gluten into the diet as well as during childhood. The optimal amount, however, has not been established.

Metrics

Metrics Loading ...

References

  1. Ludvigson JF, Leffer DA, Ciacci C, et al. The Oslo definitions for coeliac disease and related terms. Gut 2013 Jan;62(1):43-52.
  2. Husby S, Koletzko S, Korponay-Szabo IR, et al. Guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 2012; 54:136–160.
  3. Catassi C, Gatti S, Fasano A. The new epidemiology of celiac disease. J Pediatr Gastroenterol Nutr 2014;59 (suppl 1):S7–S9.
  4. Vriezinga SL, Auricchio R, Bravi E, et al. Randomized feeding intervention in infants at high risk for celiac disease. N Engl J Med 2014; 371:1304–1315
  5. Lionetti E, Castellaneta S, Francavilla R, et al. Introduction of gluten, HLA status, and the risk of celiac disease in children. N Engl J Med 2014; 371:1295–1303.
  6. Aronsson CA, Lee HS, Liu E et al, for the TEDDY Study Group. Age at gluten introduction and risk of celiac disease. Pediatrics 2015 Feb; 135(2):239-45.
  7. Aronsson CA, Lee HS, Koletzko S et al, for the TEDDY Study Group. Effects of gluten intake on risk of celiac disease. Clinical Gastroenterology and Hepatology 2016:14:403-409.
  8. Koning F. Adverse Effects of Wheat Gluten. Ann Nutr Metab 2015;67 (suppl 2):8–14
  9. Agostoni C, Decsi T, Fewtrell M, et al. Complementary feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 2008; 46:99–110.
  10. Kleinman RE, Greer FR, eds. Pediatric Nutrition Handbook. 6th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2014.
  11. Szajewska H, Shamir R, Chmielewska A, et al. Systematic review with meta-analysis: early infant feeding and coeliac disease—update 2015. Aliment Pharmacol Ther 2015; 41:1038–1054.
  12. Szajewska,H, Shamir R, Mearin L et al. Gluten introduction and risk of coeliac disease. A position paper by the ESPGHAN. JPGN 2016 Mar;62(3): 507-13.
  13. Ivarsson A, Persson LA, Nyström L, et al. Epidemic of coeliac disease in Swedish children. Acta Paediatr 2000; 89:165–171.
  14. Pinto-Sanches MI, Verdu EF, Liu E et al Gluten introduction to infant feeding and risk of celiac disease. J Pediatr. 2016; Jan;168:132-43.

How to Cite

Cavinatto, J. N. (2022). Doença celíaca e introdução do glúten na dieta infantil: avaliação dos riscos e benefícios. International Journal of Nutrology, 10(1), 294–297. https://doi.org/10.1055/s-0040-1705651