Skip to main content Skip to main navigation menu Skip to site footer
Articles
Published: 02-23-2022

Esofagite eosinofílica na infância

Hospital das Clínicas da Universidade Federal de Minas Gerais (HC/UFMG) / Professor do curso de especialização em Gastroenterologia Pediátrica do PED (UFMG) e HC (UFMG) / Vice presidente do comitê de Gastroenterologia da SMP
Eosinophilic esophagitis eosinophilia esophagitis

Abstract

Eosinophilic esophagitis is immune disease characterized by 15 or more eosinophils to microscopic biopsy of the esophageal mucosa in higher increase field. It mainly affects adults (20% in children). The clinical manifestations are vomiting, regurgitation, difficulty feeding, abdominal pain and retrosternal, dysphagia and food impaction. They vary with age. The first symptoms are more common in children. The diagnosis should only be considered after peptic disease exclusion with proton pump inhibitors. There are two options for treatment: corticosteroids for topical use in the esophageal mucosa dissolved in viscous solution for at least 8 weeks; exclusion of possible antigens - cow’s milk, egg, peanut, soy, starch, seafood, nuts and meat. Patients may progress to cure or have frequent recurrences. Many research is needed to better understand this disease.

Metrics

Metrics Loading ...

References

  1. Furuta GT, Liacouras CA, Collins MH, et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology. 2007; 133: 1342–63.
  2. Liacouras CA, Furuta GT, Hirano I, et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol. 2011; 128:3–20.
  3. Management guidelines of eosinophilic esophagitis in childhood. Papadopoulou A, Koletzko S, Heuschkel R, Dias JA, Allen KJ, Murch SH, et al. Magement guidelines of eosinophilic esophagitis in childhood.anagement guidelines of eosinophilic esophagitis in childhood. ESPGHAN, Eosinophilic Esophagitis Working Group and the Gastroenterology Committee. J Pediatr Gastroenterol Nutr. 2014; 58:107-18.
  4. DeBrosse CW, Buckmeier Butz BK, Allen CL, et al. Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia. J Allergy Clin Immunol. 2010; 126:112–9.
  5. Ronkainen J, Talley NJ, Aro P, et al. Prevalence of oesophageal eosinophils and eosinophilic oesophagitis in adults: the populationbased Kalixanda study. Gut. 2007; 56:615–20.
  6. Spergel JM, Brown-Whitehorn TF, Beausoleil JL, et al. 14 Years of eosinophilic esophagitis: clinical features and prognosis. J Pediatr Gastroenterol Nutr. 2009;48:30–6
  7. Spergel JM, Brown-Whitehorn TF, Cianferoni A, et al. Identification of causative foods in children with eosinophilic esophagitis treated with an elimination diet. J Allergy Clin Immunol. 2012; 130:461–7.
  8. Erwin EA, James HR, Gutekunst HM, et al. Serum IgE measurement and detection of food allergy in pediatric patients with eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2010; 104:496–502.
  9. Dellon ES, Gibbs WB, Fritchie KJ, et al. Clinical, endoscopic, and histologic findings distinguish eosinophilic esophagitis from gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2009; 7:1305– 13.
  10. Furuta GT, Kagalwalla AF, Lee JJ, et al. The oesophageal string test: a novel, minimally invasive method measures mucosal inflammation in eosinophilic oesophagitis. Gut. 2013;62:1395–405.
  11. Dranove JE, Horn DS, Davis MA, et al. Predictors of response to proton pump inhibitor therapy among children with significant esophageal eosinophilia. J Pediatr. 2009; 154:96–100.
  12. Spergel JM, Andrews T, Brown-Whitehorn TF, et al. Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol. 2005;95:336–43.
  13. Kelly KJ, Lazenby AJ, Rowe PC, et al. Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula. Gastroenterology. 1995; 109:1503–12.
  14. Gonsalves N, Yang G, Doerfler B, et al. Elimination diet effectively treats eosinophilic esophagitis in adults; food reintroduction identifies causative factors. Gastroenterology. 2012; 42:1451–9.
  15. Noel RJ, Putnam PE, Collins MH, et al. Clinical and immunopathologic effects of swallowed fluticasone for eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2004;2:568–75.
  16. Helou EF, Simonson J, Arora AS. 3-yr-follow-up of topical corticosteroid treatment for eosinophilic esophagitis in adults. Am J Gastroenterol. 2008; 103:2194–9.

How to Cite

Duarte, M. A. (2022). Esofagite eosinofílica na infância. International Journal of Nutrology, 10(1), 325–329. https://doi.org/10.1055/s-0040-1705658