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International Journal of Nutrology
Review
DOI: 10.1055/s-0038-1669388
Submitted: 03-06-2022
Published: 03-06-2022

O uso de whey protein no manejo da síndrome consumptiva em pacientes HIV+

Confederação Brasileira de Karate, Fortaleza, CE, Brasil / Pós-Graduação em Medicina do Esporte, Universidade Católica de Petrópolis, Petrópolis, RJ, Brasil / Pós-Graduação em Medicina do Esporte, Comitê Olímpico Internacional, Lausanne, Suiça
AIDS HIV wasting syndrome weight loss muscle mass whey protein exercise

Abstract

The aim of the present study was to perform a systematic review of the available scientific literature regarding the use of whey protein (WP) in the management of HIV wasting syndrome. The following scientific repositories were searched: PubMed/Medline, Cochrane Central Register of Controlled Trials (CENTRAL), Scielo, ScienceDirect, Europe PubMed Central (Europe PMC), LILACS (BIREME) and BVSalud. Search parameters consisted of combinations of the terms HIV, wasting syndrome, muscle mass, and whey protein, in English, Portuguese and Spanish. From these filters, three articles were identified for analysis; one article was published in AIDS, one in BMJ, and the third was published in the American Journal of Clinical Nutrition. All three studies were quantitative in nature (100%), with a combined total of 407 participants (mean = 135.7). Study volunteers were mainly female (60.7%), and volunteers had no other pathologies that could lead to muscle wasting and were not receiving anabolic treatments. The studies were performed in the United States (n = 2) and Ethiopia (n = 1). One study analyzed the effects of WP alone, one compared WP to exercise and to an association between these two, and the third study compared WP to soy protein. The main research variables were weight (n = 3), body cell mass (n = 2), fat-free mass or lean mass (n = 3), fat mass (n = 2), and muscle strength (n = 2). The results of the three studies show that WP may lead to weight gain but has no significant effect on muscle mass in HIV/AIDS wasting syndrome.

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References

  1. World Health Organization. WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children. Geneva, 2007 http://www.who.int/hiv/pub/guidelines/HIVsta-ging150307.pdf. Acessado 20 de outubro de 2017
  2. Centers for Disease Control and Prevention. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Recomm Rep. 1992 Dec 18;41(RR-17):1–19. https://www.cdc.gov/mmwr/preview /mmwrhtml/00018871.htm. Acessado 20 de outubro de 2017
  3. Coodley GO, Loveless MO, Merrill TM. The HIV wasting syndrome: a review. J Acquir Immune Defic Syndr 1994;7(07):681–694
  4. Dudgeon WD, Phillips KD, Carson JA, Brewer RB, Durstine JL, Hand GA. Counteracting muscle wasting in HIV-infected individuals. HIV Med 2006;7(05):299–310
  5. Grinspoon S, Mulligan K; Department of Health and Human Services Working Group on the Prevention and Treatment of Wasting and Weight Loss. Weight loss and wasting in patients infected with human immunodeficiency virus. Clin Infect Dis 2003;36(02, Suppl 2):S69–S78
  6. O’Brien K, Tynan AM, Nixon S, Glazier RH. Effects of progressive resistive exercise in adults living with HIV/AIDS: systematic review and meta-analysis of randomized trials. AIDS Care 2008; 20(06):631–653
  7. Yarasheski KE, Roubenoff R. Exercise treatment for HIV-associated metabolic and anthropomorphic complications. Exerc Sport Sci Rev 2001;29(04):170–174
  8. Zinna EM, Yarasheski KE. Exercise treatment to counteract protein wasting of chronic diseases. Curr Opin Clin Nutr Metab Care 2003;6(01):87–93
  9. Malita FM, Karelis AD, Toma E, Rabasa-Lhoret R. Effects of different types of exercise on body composition and fat distribution in HIV-infected patients: a brief review. Can J Appl Physiol 2005;30(02):233–245
  10. Tang AM, Quick T, Chung M, Wanke CA. Nutrition assessment, counseling, and support interventions to improve health-related outcomes in people living with HIV/AIDS: a systematic review of the literature. J Acquir Immune Defic Syndr 2015;68(03, Suppl 3):S340–S349
  11. Alo C, Ogbonnaya LU, Azuogu BN. Effects of nutrition counseling and monitoring on the weight and hemoglobin of patients receiving antiretroviral therapy in Ebonyi State, Southeast Nigeria. HIV AIDS (Auckl) 2014;6:91–97
  12. Michaelsen KF. Cow’s milk in the prevention and treatment of stunting and wasting. Food Nutr Bull 2013;34(02):249–251
  13. Moreno YF, Sgarbieri VC, da Silva MN, Toro AA, Vilela MM. Features of whey protein concentrate supplementation in children with rapidly progressive HIV infection. J Trop Pediatr 2006;52(01):34–38
  14. Evans D, McNamara L, Maskew M, et al. Impact of nutritional supplementation on immune response, body mass index and bioelectrical impedance in HIV-positive patients starting antiretroviral therapy. Nutr J 2013;12(01):111
  15. Koethe JR, Chi BH, Megazzini KM, Heimburger DC, Stringer JS. Macronutrient supplementation for malnourished HIV-infected adults: a review of the evidence in resource-adequate and resource-constrained settings. Clin Infect Dis 2009;49(05):787–798
  16. Op den Kamp CM, Langen RC, Haegens A, Schols AM. Muscle atrophy in cachexia: can dietary protein tip the balance? Curr Opin Clin Nutr Metab Care 2009;12(06):611–616
  17. Sztam KA, Fawzi WW, Duggan C. Macronutrient supplementation and food prices in HIV treatment. J Nutr 2010;140(01):213S–223S
  18. Swaminathan S, Padmapriyadarsini C, Yoojin L, et al. Nutritional supplementation in HIV-infected individuals in South India: a prospective interventional study. Clin Infect Dis 2010;51(01):51–57
  19. Hoppe C, Andersen GS, Jacobsen S, et al. The use of whey or skimmed milk powder in fortified blended foods for vulnerable groups. J Nutr 2008;138(01):145S–161S
  20. Bounous G, Baruchel S, Falutz J, Gold P. Whey proteins as a food supplement in HIV-seropositive individuals. Clin Invest Med 1993;16(03):204–209
  21. Madureira AR, Pereira CI, Gomes AM, Pintado ME, Malcata FX. Bovine whey proteins–Overview on their main biological properties. Food Res Int 2007;40(10):1197–1211
  22. Hoffman JR, Falvo MJ. Protein–which is best? J Sports Sci Med 2004;3(03):118–130
  23. Agin D, Gallagher D, Wang J, Heymsfield SB, Pierson RN Jr, Kotler DP. Effects of whey protein and resistance exercise on body cell mass, muscle strength, and quality of life in women with HIV. AIDS 2001;15(18):2431–2440
  24. Olsen MF, Abdissa A, Kæstel P, et al. Effects of nutritional supplementation for HIV patients starting antiretroviral treatment: randomised controlled trial in Ethiopia. BMJ 2014;348:g3187
  25. Sattler FR, Rajicic N, Mulligan K, et al; ACTG 392 Study Team. Evaluation of high-protein supplementation in weight-stable HIV-positive subjectswith a history of weightloss: a randomized, double-blind, multicenter trial. Am J Clin Nutr 2008;88(05):1313–1321
  26. About BMJ. The BMJ. http://www.bmj.com/about-bmj. Acessado 19 de outubro de 2017
  27. Scijournal.org. Medicine journal impact factor list. http://www.scijournal.org/medicine-journal-impact-factor-list.shtml. Acessado 07de dezembro de 2017
  28. Joint United Nations Programme on HIV/AIDS. Global AIDS update 2016. Geneva: UNAIDS; 2016
  29. Mangili A, Murman DH, Zampini AM, Wanke CA. Nutrition and HIV infection: review of weight loss and wasting in the era of highly active antiretroviral therapy from the nutrition for healthy living cohort. Clin Infect Dis 2006;42(06):836–842
  30. Coodley GO, Loveless MO, Nelson HD, Coodley MK. Endocrine function in the HIV wasting syndrome. J Acquir Immune Defic Syndr 1994;7(01):46–51
  31. Erlandson KM, Li X, Abraham AG, et al. Long-term impact of HIV wasting on physical function. AIDS 2016;30(03):445–454
  32. Li N, Spiegelman D, Drain P, et al. Predictors of weight loss after HAART initiation among HIV-infected adults in Tanzania. AIDS 2012;26(05):577–585
  33. Kosmiski L. Energy expenditure in HIV infection. Am J Clin Nutr 2011;94(06):1677S–1682S
  34. Klassen K, Goff LM. Dietary intakes of HIV-infected adults in urban UK. Eur J Clin Nutr 2013;67(08):890–893
  35. Duggal S, Chugh TD, Duggal AK. HIV and malnutrition: effects on immune system. Clin Dev Immunol 2012;2012:784740
  36. Dibari F, Bahwere P, Le Gall I, Guerrero S, Mwaniki D, Seal A. A qualitative investigation of adherence to nutritional therapy in malnourished adult AIDS patients in Kenya. Public Health Nutr 2012;15(02):316–323
  37. Chandrasekhar A, Gupta A. Nutrition and disease progression prehighly active antiretroviral therapy (HAART) and post-HAART: can good nutrition delay time to HAART and affect response to HAART? Am J Clin Nutr 2011;94(06):1703S–1715S
  38. Anand D, Puri S. Nutritional knowledge, attitude, and practices among HIV-positive individuals in India. J Health Popul Nutr 2013;31(02):195–201
  39. Argemi X, Dara S, You S, et al. Impact of malnutrition and social determinants on survival of HIV-infected adults starting antiretroviral therapy in resource-limited settings. AIDS 2012;26(09):1161–1166
  40. Tiyou A, Belachew T, Alemseged F, Biadgilign S. Food insecurity and associated factors among HIV-infected individuals receiving highly active antiretroviral therapy in Jimma zone Southwest Ethiopia. Nutr J 2012;11(01):51
  41. Coppini LZ, Jesus R. Terapia Nutricional na Síndrome da Imunodeficiência Adquirida (HIV/AIDS). Associação Médica Brasileira e Conselho Federal de Medicina. 2011
  42. World Health Organization. Nutrient requirements for people living with HIV: Report of a technical consultation. 2003
  43. Filteau S, PrayGod G, Woodd SL, et al. Nutritional status is the major factor affecting grip strength of African HIV patients before and during antiretroviral treatment. Trop Med Int Health 2017; 22(10):1302–1313
  44. Tipton KD, Elliott TA, Cree MG, Wolf SE, Sanford AP, Wolfe RR. Ingestion of casein and whey proteins result in muscle anabolism after resistance exercise. Med Sci Sports Exerc 2004; 36(12):2073–2081
  45. Tipton KD, Wolfe RR. Exercise, protein metabolism, and muscle growth. Int J Sport Nutr Exerc Metab 2001;11(01):109–132
  46. Cribb PJ, Williams AD, Stathis CG, Carey MF, Hayes A. Effects of whey isolate, creatine, and resistance training on muscle hypertrophy. Med Sci Sports Exerc 2007;39(02):298–307
  47. Cribb PJ, Hayes A. Effects of supplement timing and resistance exercise on skeletal muscle hypertrophy. Med Sci Sports Exerc 2006;38(11):1918–1925
  48. Hayes A, Cribb PJ. Effect of whey protein isolate on strength, body composition and muscle hypertrophy during resistance training. Curr Opin Clin Nutr Metab Care 2008;11(01):40–44
  49. Reidy PT, Walker DK, Dickinson JM, et al. Protein blend ingestion following resistance exercise promotes human muscle protein synthesis. J Nutr 2013;143(04):410–416
  50. Hulmi JJ, Tannerstedt J, Selänne H, Kainulainen H, Kovanen V, Mero AA. Resistance exercise with whey protein ingestion affects mTOR signaling pathway and myostatin in men. J Appl Physiol (1985) 2009;106(05):1720–1729
  51. Little JP, Phillips SM. Resistance exercise and nutrition to counteract muscle wasting. Appl Physiol Nutr Metab 2009;34(05):817–828
  52. Marshall K. Therapeutic applications of whey protein. Altern Med Rev 2004;9(02):136–156
  53. Patel S. Functional food relevance of whey protein: A review of recent findings and scopes ahead. J Funct Foods 2015;19:308–319
  54. Yalçin AS. Emerging therapeutic potential of whey proteins and peptides. Curr Pharm Des 2006;12(13):1637–1643
  55. Kerasioti E, Stagos D, Jamurtas A, et al. Anti-inflammatory effects of a special carbohydrate-whey protein cake after exhaustive cycling in humans. Food Chem Toxicol 2013;61:42–46
  56. Ha E, Zemel MB. Functional properties of whey, whey components, and essential amino acids: mechanisms underlying health benefits for active people (review). J Nutr Biochem 2003;14(05):251–258
  57. Wong CW, Watson DL. Immunomodulatory effects of dietary whey proteins in mice. J Dairy Res 1995;62(02):359–368
  58. Coodley GO, Coodley MK, Nelson HD, Loveless MO; GO. Micronutrient concentrations in the HIV wasting syndrome. AIDS 1993; 7(12):1595–1600
  59. Micke P, Beeh KM, Schlaak JF, Buhl R. Oral supplementation with whey proteins increases plasma glutathione levels of HIV-infected patients. Eur J Clin Invest 2001;31(02):171–178
  60. Mollahosseini M, Shab-Bidar S, Rahimi MH, Djafarian K. Effect of whey protein supplementation on long and short term appetite: A meta-analysis of randomized controlled trials. Clin Nutr ESPEN 2017;20:34–40
  61. Ott M, Fischer H, Polat H, et al. Bioelectrical impedance analysis as a predictor of survival in patients with human immunodeficiency virus infection. J Acquir Immune Defic Syndr Hum Retrovirol 1995;9(01):20–25

How to Cite

Naidu, S. T. (2022). O uso de whey protein no manejo da síndrome consumptiva em pacientes HIV+. International Journal of Nutrology, 11(2), 42–50. https://doi.org/10.1055/s-0038-1669388