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International Journal of Nutrology
Review
DOI: 10.1055/s-0039-1678705
Submitted: 03-06-2022
Published: 03-06-2022

Use of Antioxidants in Cardiovascular Surgery

União das Faculdades dos Grandes Lagos- UNILAGO, Brazil
União das Faculdades dos Grandes Lagos- UNILAGO, Brazil
União das Faculdades dos Grandes Lagos- UNILAGO, Brazil
coronary artery bypass grafting cardiopulmonary bypass (CPB) reactive oxygen species (ROS)

Abstract

Morbidity and mortality due to postoperative complications, related to inflammation and systemic oxidative stress, of coronary artery bypass grafting is high and inadmissible. It is suggested that numerous adverse outcomes may be caused by the systemic effect of cardiopulmonary bypass (CPB). One of the most damaging consequences of these events is the formation of reactive oxygen species (ROS) and radicals, which originate from a variety of cellular and enzymatic sources, such as myocardial cells, activated neutrophils, or endothelial xanthine oxidase. Many studies have described the nature of these ROS and the time of their formation during CPB. With the goal of reducing these damages, studies have investigated the use of antioxidant supplements during CPB. The present study focused on the time course of the innate antioxidant activity (antioxidant enzymes and overall antioxidant capacity in plasma) in patients undergoing CABG. The methodology used was the literature review.

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References

  1. Prasad AS. Clinical, immunological, anti-inflammatory and antioxidant roles of zinc. Exp Gerontol 2008; 43 (05) 370-377
  2. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007; 39 (01) 44-84
  3. Beretta G, Aldini G, Facino RM, Russell RM, Krinsky NI, Yeum KJ. Total antioxidant performance: a validated fluorescence assay for the measurement of plasma oxidizability. Anal Biochem 2006; 354: 290-298
  4. Penckofer S, Schwertz D, Florczak K. Oxidative stress and cardiovascular disease in type 2 diabetes: the role of antioxidants and pro-oxidants. J Cardiovasc Nurs 2002; 16 (02) 68-85
  5. Callegaro GD, Koerich C, Lanzoni Gde M, Baggio MA, Erdmann AL. Significance of myocardial revascularization surgery: changes in lifestyle. Rev Gauch Nurs 2012; 33 (04) 149-156
  6. Koerich C, Baggio MA, Erdmann AL, Lanzoni Gde M, Higashi GDC. Myocardial revascularization: strategies for coping with the disease and the surgical process. Acta Paul Nurs 2013; 26 (01) 8-13
  7. Susanne Rautiainen Emily B, Levitan Murray A, Mittleman Alicja Wolk. Fruit and vegetable intake and rate of heart failure: a population?based prospective cohort of women. First published: 08 November 2014 https://doi.org/10.1002/ejhf.191 Cited by: 18
  8. Quintana JF, Kalil RAK. Cardiac surgery: psychological manifestations of the patient in the pre and postoperative period. Psicol Hosp (Sao Paulo) 2012; 10 (02) 17-32
  9. COSTA. Rui Pedro. Surgery of bypass coronary artery without extracorporeal circulation: evolution and application. 2016. Available at: https://repositorio-aberto.up.pt/bitstream/10216/90705/2/173221.pdf . Accessed on June 2, 2018.
  10. Couto MAL, Canniatti-Brazaca SG. Quantification of vitamin C and antioxidant capacity of citrus varieties. Food Sci Tech 2010; 30 (01) 15-19
  11. CHORILLI. Marlus. Free radicals and antioxidants: fundamental concepts for application in pharmaceutical and cosmetic formulations. 2007. Available at: http://rbfarma.org.br/files/PAG_113a118_RADICAIS.pdf . Accessed on June 2, 2018
  12. Stahl W, Sies H. Antioxidant defense: vitamins E and C and carotenoids. Diabetes 1997; 46 (02) (Suppl. 02) S14-S18
  13. Diaz MN, Frei B, Vita JA, Keaney Jr JF. Antioxidants and atherosclerotic heart disease. N Engl J Med 1997; 337 (06) 408-416
  14. Ferrari R, Alfieri O, Curello S. , et al. Occurrence of oxidative stress during reperfusion of the human heart. Circulation 1990; 81 (01) 201-211
  15. Nowicki R, Saczko J, Kulbacka J. , et al. The estimation of oxidative stress markers and apoptosis in right atrium auricles cardiomyocytes of patients undergoing surgical heart revascularization with the use of warm blood cardioplegia. Folia Histochemica et Cytobiologica 2010; 48 (02) 202-207
  16. SARMENTO. Roberta Aguiar. Micronutrients Antioxidants and Cardiovascular Risk in Patients with Diabetes: A Systematic Review. Brazilian Archives of Cardiology, 2013
  17. Arduini A, Mezzet A, Porecca E, Lapenna D, DeJulia J, Marzio L, Polidoro G, Cuccurullo F. Effect of ischemia reperfusion on antioxidant enzymes and mitochondrial inner membraneproteins in perfused rat heart. Biochim Biophys Acta 1988; 970: 113-21
  18. MESQUITA. Braulio Fortes et al. Inflammatory response in extracorporeal circulation: therapeutic strategies. 2017. Available at: http://rmmg.org/artigo/detalhes/1027 . Accessed on June 2, 2018.
  19. Barsacchi R, Pelosi G, Maffei S, Baroni M, Salvatore L, Ursini F, Verunelli F, Biagini A. Myocardial vitamin E is consumed during cardiopulmonary bypass: indirect evidence of free radical generation in human ischemic heart. Int J Cardiol 1992; 37: 339-343
  20. Ballmer PE, Reinhart WH, Jordan P, Buhler M, Moser UK, Gey KF. Depletion of plasma vit C but not of vit E in response to cardiac operations. J Thorac Cardiovasc Surg 1994; 108: 311-320
  21. Jorens PG, De Jongh RF, De Backer WA, Van Damme J, van Overveld FJ, Bossaert L, Walter P, Herman AG, Rampart M. Interleukin-8 production in patients undergoing cardiopulmonary bypass. The influence of pre-treatment with methylprednisolone. Am Rev Respir Dis 1993; 148: 890-895
  22. Callegaro GD, Koerich C, Lanzoni GM, de M, Baggio MA, Erdmann AL. Significando o processo de viver a cirurgia de revascularização miocárdica: mudanças no estilo de vida. Rev Gauch Enferm 2012; 33 (04) 149-156
  23. Factors that influence the process of living cardiac revascularization. Texto Contexto Enferm 2015; [periodical on the Internet]
  24. KNIHS. Neide da Silva. Path traveled to cardiac surgery: needs and expectations in the preoperative period. 2017. Available at: http://www.scielo.org.co/pdf/aven/v35n1/v35n1a04.pdf . Accessed on June 2, 2018

How to Cite

Gabriel, E. A., Mazza, C. A., & Mello, M. A. J. de. (2022). Use of Antioxidants in Cardiovascular Surgery. International Journal of Nutrology, 11(3), 80–86. https://doi.org/10.1055/s-0039-1678705