Skip to main content Skip to main navigation menu Skip to site footer
Articles
Published: 27-01-2023

Investigation of hypovitaminosis D in patients infected with SARS-CoV-2 and its relationship with clinical worsening: a cross-sectional observational retrospective clinical study

José Alencar Regional Hospital, Public health of Triângulo Mineiro Southern Macroregion, Uberaba, Minas Gerais, Brazil
University of São Paulo (USP), São Paulo, Brazil
University of Uberaba (Uniube), Minas Gerais, Brazil
Federal University of São Carlos (Ufscar), São Paulo, Brazil
Federal University of Santa Catarina (UFSC), Santa Catarina, Brazil
José Alencar Regional Hospital, Public health of Triângulo Mineiro Southern Macroregion, Uberaba, Minas Gerais, Brazil
José Alencar Regional Hospital, Public health of Triângulo Mineiro Southern Macroregion, Uberaba, Minas Gerais, Brazil
José Alencar Regional Hospital, Public health of Triângulo Mineiro Southern Macroregion, Uberaba, Minas Gerais, Brazil
José Alencar Regional Hospital, Public health of Triângulo Mineiro Southern Macroregion, Uberaba, Minas Gerais, Brazil
José Alencar Regional Hospital, Public health of Triângulo Mineiro Southern Macroregion, Uberaba, Minas Gerais, Brazil
SARS-CoV-2 Vitamin D COVID-19 evolution Hypovitaminosis

Abstract

Numerous studies have demonstrated the profile of infection and symptoms related to COVID-19 that occur with pulmonary manifestations (such as Acute Respiratory Syndrome), digestive symptoms, anosmia, and ageusia. Many comorbidities have been associated with deaths and severe cases of the disease, such as diabetes, hypertension, obesity, and heart disease. However, many questions remain unanswered, especially the association of disease severity with hypovitaminosis D. Vitamin D deficiency is widely found in patients in Intensive Care Units, and recent studies have shown that it has been suggested that patients with severe manifestations of COVID-19 have hypovitaminosis D. Therefore, the present study aims to associate the presence of hypovitaminosis D in patients with the acute respiratory syndrome, positive for SARS-COV-2, admitted to the José Alencar Regional Hospital in Uberaba/Brazil and the evolution of the disease (days of hospitalization, hospitalization in the ICU, discharge and death) through the analysis of vitamin D (25(OH)D) hospitalized patients clinical records. The incidence of hypovitaminosis D among the patients was also assessed. The results may contribute to the understanding of the disease, as well as the need for vitamin supplementation.

Metrics

Metrics Loading ...

References

  1. Jin Yuefei, Yang, Haiyan JI, Wangquan et al. Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses, 2020, v. 12, n. 4, p. 372. Available at: . Accessed on: 24 abr. 2020.
  2. Zhou P. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, [s. l.], v. 579, p. 270-273, 2020. DOI https://doi.org/10.1038/s41586-020-2012-7.
  3. Guan WJ, Liang WH, Zhao Y, Liang HR, Chen ZS, Li YM, Liu XQ, Chen RC, Tang CL, Wang T, Ou CQ, Li L, Chen PY, Sang L, Wang W, Li JF, Li CC, Ou LM, Cheng B, Xiong S, Ni ZY, Xiang J, Hu Y, Liu L, Shan H, Lei CL, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Cheng LL, Ye F, Li SY, Zheng JP, Zhang NF, Zhong NS, He JX; China Medical Treatment Expert Group for COVID-19. Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis. Eur Respir J. 2020 May 14;55(5):2000547. doi: 10.1183/13993003.00547-2020.
  4. Ribas Filho D, De Almeida CAN, De Oliveira Filho AE. Posicionamento atual sobre vitamina D na prática clínica: Posicionamento da Associação Brasileira de Nutrologia (Abran). International Journal of Nutrology, 2020, v. 12, n. 03, p. 082- 096.
  5. Premaor MO, Furlanetto TW. Hipovitaminose D em adultos: entendendo melhor a apresentação de uma velha doença. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 50, n. 1, p. 25-37, 2006.
  6. Kratz DB, Silva GS, Tenfen A. Deficiência de vitamina D (250H) e seu impacto na qualidade de vida: uma revisão de literatura. RBAC, 2018, v. 50, n. 2, p. 118- 23.
  7. Mulligan ML. et al. Implications of vitamin D deficiency in pregnancy and lactation. American journal of obstetrics and gynecology, v. 202, n. 5, p. 429. e1- 429. e9, 2010.
  8. Tieland M. et al. Low vitamin D status is associated with reduced muscle mass and impaired physical performance in frail elderly people. European journal of clinical nutrition, 2013, v. 67, n. 10, p. 1050-1055.
  9. Maeda SS et al. Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D. Arq Bras Endocrinol Metab, 2014, v. 58, n. 5, p. 411-33.
  10. Martineau AR. et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. bmj, v. 356, 2017
  11. Hansdottir Sif et al. Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense. The Journal of Immunology, v. 181, n. 10, p. 7090-7099, 2008.
  12. Hewison M. Antibacterial effects of vitamin D. Nature Reviews Endocrinology, 2011, v. 7, n. 6, p. 337-345.
  13. Silvino VO et al. Vitamin D and infectious diseases in the COVID-19 pandemic outburst. Research, Society and Development, 2020, v. 9, n. 7.
  14. Cavalcante LFP et al. Impacto da deficiência de vitamina D em pacientes de unidade de terapia intensiva. Rev Bras Nutr Clin, 2015, v. 30, n. 4, p. 354-8.
  15. Marques CDL et al. A importância dos níveis de vitamina D nas doenças autoimunes. Revista Brasileira de Reumatologia, 2010, v. 50, n. 1, p. 67-80.
  16. Hadizadeh, Fatemeh. Supplementation with vitamin D in the COVID-19 pandemic?. Nutrition Reviews, 2020.
  17. Hu, Jieyu et al. Changes in the calcium-parathyroid hormone-vitamin d axis and prognosis for critically ill patients: a prospective observational study. PLoS One, 2013, v. 8, n. 9, p. e75441.
  18. Laird, E. et al. Vitamin D and inflammation: potential implications for severity of COVID-19. Irish med J, 2020, v. 113, n. 5, p. P81.
  19. Alipio, Mark. Vitamin D Supplementation Could Possibly Improve Clinical Outcomes of Patients Infected with Coronavirus-2019 (COVID-19). Available at SSRN 3571484, 2020.
  20. Meltzer et al. Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results. JAMA Network Open. 2020; 3(9):e2019722.doi:10.1001/jamanetworkopen.2020.19722.
  21. Greiller CL, Martineau AR. Modulation of the immune response to respiratory viruses by vitamin D. Nutrients, 2015, v. 7, n. 6, p. 4240-4270.
  22. CDC. Centers for Disease Control and Prevention. Coronavirus Disease 2019 (COVID-19): People with certain medical conditions. Access in: https://www.cdc.gov/coronavirus/2019-ncov/needextra-precautions/people-withmedical-conditions.html.2021.
  23. Peters BS, dos Santos LC, Fisberg M, Wood RJ, Martini LA. Prevalence of vitamin D insufficiency in Brazilian adolescents. Ann Nutr Metab 2009;54(01):15–21. Doi: 10.1159/000199454.2009.
  24. de Carvalho Mesquita K, de Souza Machado Igreja AC, Costa IMC. Dermatite atópica e vitamina D: Fatos e controvérsias. An BrasDermatol 2013;88(06):945– 953. Doi: 10.1590/abd1806-4841.20132660.2013.
  25. Vieira et al. Vitamin D Deficiency in Brazil: Questions about Potential Causes and Clinical Characteristics. Int J Nutrol 2021; 14:26–32. DOI https://doi.org/10.1055/s-0041-1728682.2021.
  26. Pearce N. What does the odds ratio estimate in a case-control study? Int J Epidemiol. 1993;22(6):1189-92.
  27. Oliveira AM. et al. Understanding the clinical research IV: case-control studies. FEMINA | Julho/Agosto 2015 | vol 43 | nº 4.2015.

How to Cite

Vilela, M. A. C., Caetano, J. A., Martins, R. D. N. G., Pereira Filho, E. R., Pilotto, M. R., Carvalho, E. F. da S., Martins, G. C. da S. C., Lopes, L. de M., Reck, D. A., & Ramos, F. G. (2023). Investigation of hypovitaminosis D in patients infected with SARS-CoV-2 and its relationship with clinical worsening: a cross-sectional observational retrospective clinical study. International Journal of Nutrology, 15(4). https://doi.org/10.54448/ijn22403