Skip to main content Skip to main navigation menu Skip to site footer
International Journal of Nutrology
Review
DOI: 10.54448/ijn23201
Submitted: 03-17-2023
Published: 03-17-2023

Major evidence of clinical studies on the triad gut microbiota, ubiquinone and physical exercise: a systematic review

Dra. Fernanda Schmechel Clinic (Nutrology Physician) - Rio Grande do Sul, Torres, Brazil / UCPEL - Catholic University of Pelotas (Universidade Católica de Pelotas), Rio Grande do Sul, Brazil.
Physical exercise Sports performance Gut microbiota Ubiquinone

Abstract

Introduction: In the scenario of sports practices, the human gut microbiota is currently the focus of convergent interest in many diseases and sports performance. Sports performance studies have also shown interesting and promising results. Supplementation with certain antioxidants such as ubiquinone [Coenzyme Q10 (CoQ10)] is important for physically active individuals to speed recovery from fatigue and prevent exercise damage. Objective: It was to demonstrate the influence of the gut microbiota and ubiquinone on the performance of athletes. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from September to November 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: 104 articles were found. A total of 54 articles were evaluated and 27 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 13 studies with a high risk of bias and 27 studies that did not meet GRADE. Most studies showed homogeneity in their results, with X 2 =97.2% >50%. The composition and activity of the gut microbiota are influenced by many different factors, such as diet and physical activity. Cumulative data indicate that gut bacteria are sensitive to modulation by physical activity, as demonstrated by studies using models of training and hypoactivity. Supplementation with the antioxidant Coenzyme Q10 is important for physically active individuals to accelerate recovery from fatigue and prevent damage caused by exercise, in addition to optimizing training and improving sports performance. Clinical studies have shown that in physical fatigue concerning physical exercise, patients have low plasma concentrations of Coenzyme Q10.

Metrics

Metrics Loading ...

References

  1. Boisseau N, Barnich N, Koechlin-Ramonatxo C. The Nutrition-Microbiota-Physical Activity Triad: An Inspiring New Concept for Health and Sports Performance. Nutrients. 2022 Feb 22;14(5):924. doi: 10.3390/nu14050924.
  2. Cella V, Bimonte VM, Sabato C, Paoli A, Baldari C, Campanella M, Lenzi A, Ferretti E, Migliaccio S. Nutrition and Physical Activity-Induced Changes in Gut Microbiota: Possible Implications for Human Health and Athletic Performance. Foods. 2021 Dec 10;10(12):3075. doi: 10.3390/foods10123075.
  3. Bonomini-Gnutzmann R, Plaza-Díaz J, Jorquera-Aguilera C, Rodríguez-Rodríguez A, Rodríguez-Rodríguez F. Effect of Intensity and Duration of Exercise on Gut Microbiota in Humans: A Systematic Review. Int J Environ Res Public Health. 2022 Aug 3;19(15):9518. doi: 10.3390/ijerph19159518.
  4. Drobnic F, Lizarraga MA, Caballero-García A, Cordova A. Coenzyme Q10 Supplementation and Its Impact on Exercise and Sport Performance in Humans: A Recovery or a Performance-Enhancing Molecule? Nutrients. 2022 Apr 26;14(9):1811. doi: 10.3390/nu14091811.
  5. Ovchinnikov AN, Deryugina AV, Paoli A. Royal Jelly Plus Coenzyme Q10 Supplementation Enhances High-Intensity Interval Exercise Performance via Alterations in Cardiac Autonomic Regulation and Blood Lactate Concentration in Runners. Front Nutr. 2022 Jun 23;9:893515. doi: 10.3389/fnut.2022.893515.
  6. Rankin A, O’Donovan C, Madigan SM, O'Sullivan O, Cotter PD. 'Microbes in sport' -The potential role of the gut microbiota in athlete health and performance. Br J Sports Med. 2017 May;51(9):698-699. doi: 10.1136/bjsports-2016-097227. Epub 2017 Jan 25.
  7. O'Sullivan O, Cronin O, Clarke SF, et al. Exercise and the microbiota. Gut Microbes 2015;6:131–6.
  8. Bermon S, Petriz B, Kajėnienė A, et al. The microbiota: an exercise immunology perspective. Exerc Immunol Rev 2015;21:70–9.
  9. Leclercq S, Forsythe P, Bienenstock J. Posttraumatic stress disorder: Does the gut microbiome hold the key? Can J Psychiatry 2016;61:204–13.
  10. Steves CJ, Bird S, Williams FM, et al. The microbiome and musculoskeletal conditions of aging: A review of evidence for impact and potential therapeutics. J Bone Miner Res 2016;31:261–9.
  11. Ohlsson C, Sjögren K. Effects of the gut microbiota on bone mass. Trends Endocrinol Metab 2015;26:69–74.
  12. Turnbaugh PJ, Ley RE, Mahowald MA, et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006;444:1027–31.
  13. Hsu YJ, Chiu CC, Li YP, et al. Effect of intestinal microbiota on exercise performance in mice. J Strength Cond Res 2015;29:552–8. Nutrients. 2019 Jan 24;11(2). pii: E261. doi: 10.3390/nu11020261.
  14. Murtaza N, Burke LM, Vlahovich N, Charlesson B, O' Neill H, Ross ML, Campbell KL, Krause L, Morrison M. The Effects of Dietary Pattern during Intensified Training on Stool Microbiota of Elite Race Walkers. mSystems. 2018 Apr 24;3(3). pii: e00044-18. doi: 10.1128/mSystems.00044-18. eCollection 2018 May-Jun.
  15. Cronin O, Barton W, Skuse P, Penney NC, Garcia-Perez I, Murphy EF, Woods T, Nugent H, Fanning A, Melgar S, Falvey EC, Holmes E, Cotter PD, O'Sullivan O, Molloy MG, Shanahan F. A Prospective Metagenomic and Metabolomic Analysis of the Impact of Exercise and/or Whey Protein Supplementation on the Gut Microbiome of Sedentary Adults. mSystems. 2018 Apr 24;3(3). pii: e00044-18. doi: 10.1128/mSystems.00044-18. eCollection 2018 May-Jun.
  16. Moreno-Pérez D, Bressa C, Bailén M, Hamed-Bousdar S, Naclerio F, Carmona M, Pérez M, González-Soltero R, Montalvo-Lominchar MG, Carabaña C, Larrosa M. Effect of a Protein Supplement on the Gut Microbiota of Endurance Athletes: A Randomized, Controlled, Double-Blind Pilot Study. Nutrients. 2018 Mar 10;10(3). pii: E337. doi: 10.3390/nu10030337.
  17. Clark A, Mach N. Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes. J Int Soc Sports Nutr. 2016 Nov 24;13:43. eCollection 2016.
  18. Strasser B, Geiger D, Schauer M, Gostner JM, Gatterer H, Burtscher M, Fuchs D. Probiotic Supplements Beneficially Affect Tryptophan-Kynurenine Metabolism and Reduce the Incidence of Upper Respiratory Tract Infections in Trained Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial. Nutrients. 2016 Nov 23;8(11). pii: E752.
  19. Tóth Š, Šajty M, Pekárová T, Mughees A, Štefanič P, Katz M, Spišáková K, Pella J, Pella D. Addition of omega-3 fatty acid and coenzyme Q10 to statin therapy in patients with combined dyslipidemia. J Basic Clin Physiol Pharmacol. 2017.
  20. Littaru G, Langsjoen P. Coenzyme Q10 and statins: Biochemical and clinical implications. Mitochondrion, 2007, 7: S168-S174.
  21. Littaru G, Langsjoen P. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Molecular Biotechnology, 2007, 37(1):31-37. Mitochondrion, 2007, 7: S168-S174.
  22. Littaru G, Langsjoen P. Clinical aspects of coenzyme Q10: an update. Nutrition, 2010, 26(3): 250-254.
  23. Emami A, Bazargani-Gilani B. Effect of oral CoQ10 supplementation along with precooling strategy on cellular response to oxidative stress in elite swimmers. Food Funct. 2018 Aug 15;9(8):4384-4393. doi: 10.1039/c8fo00960k.
  24. Orlando P, Silvestri S, Galeazzi R, Antonicelli R, Marcheggiani F, Cirilli I, Bacchetti T, Tiano L. Effect of ubiquinol supplementation on biochemical and oxidative stress indexes after intense exercise in young athletes. Redox Rep. 2018 Dec;23(1):136-145. doi: 10.1080/13510002.2018.1472924.
  25. Bjørklund G, Dadar M, Pen JJ, Chirumbolo S, Aaseth J. Chronic fatigue syndrome (CFS): Suggestions for a nutritional treatment in the therapeutic approach. Biomed Pharmacother. 2019 Jan;109:1000-1007. doi: 10.1016/j.biopha.2018.10.076. Epub 2018 Nov 5.
  26. Fenn K, Strandwitz P, Stewart EJ, Dimise E, Rubin S, Gurubacharya S, Clardy J, Lewis K. Quinones are growth factors for the human gut microbiota. Microbiome. 2017 Dec 20;5(1):161. doi: 10.1186/s40168-017-0380-5.
  27. Ravcheev DA, Thiele I. Genomic Analysis of the Human Gut Microbiome Suggests Novel Enzymes Involved in Quinone Biosynthesis. Front Microbiol. 2016 Feb 9;7:128. doi: 10.3389/fmicb.2016.00128. eCollection 2016.

How to Cite

Schmechel, F. R. (2023). Major evidence of clinical studies on the triad gut microbiota, ubiquinone and physical exercise: a systematic review. International Journal of Nutrology, 16(2). https://doi.org/10.54448/ijn23201