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Review
Published: 08-06-2023

Major approaches to the skin-gut microbiota axis under the light of the nutrology of probiotics and prebiotics: a systematic review

Estação Saúde Brasil Clinic, Araguaína, Centro, Tocantins, Brazil
Healthy skin Gut microbiota Nutrology Probiotics Prebiotics

Abstract

Introduction: Skin conditions contributed with about 2.0% to the global burden of 306 diseases and injuries in recent years. The microbiota compositions of lesional skin in atopic dermatitis and psoriasis showed distinct differences compared to healthy skin, as well as healthy skin presented a healthy gut microbiota in the light of nutrology. Objective: It was to analyze, through a systematic review, the main considerations on the Skin-Gut microbiota axis, presenting the importance of intestinal health through nutrology, probiotics and prebiotics. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from August to October 2022 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results: A total of 255 articles were found. A total of 76 articles were evaluated in full and 20 articles were included. Current scientific evidence reveals the existence of an important Skin-Gut microbiota axis in the presence of nutrients responsible for this, highlighting the management of dermatoses through probiotics and prebiotics, as well as changes in lifestyle. Conclusion: Management of aesthetically healthy skin includes manipulation of bowel function. Treatments that augment or repair a leaky gut barrier may become important as adjunctive therapy in the management of inflammatory skin conditions and may help to enhance the effectiveness of standard dermal therapy.

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References

  1. Sinha S, Lin G, Ferenczi K. The skin microbiome and the gut-skin axis. Clin Dermatol. [Internet] 2021, Sep-Oct [citado 2022 junho 10]; 39(5):829-839. doi: 10.1016/j.clindermatol.2021.08.021. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34785010/
  2. Olejniczak-Staruch I, Ciążyńska M, Sobolewska-Sztychny D, Narbutt J, Skibińska M, Lesiak A. Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis. Int J Mol Sci. [Internet] 2021 Apr 13 [citado 2022 junho 15]; 22(8):3998. doi: 10.3390/ijms22083998. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33924414/.
  3. Fang Z, Li L, Zhang H, Zhao J, Lu W, Chen W. Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review. Front Immunol. [Internet] 2021 Jul 14 [citado 2022 junho 15]; 12:720393. doi: 10.3389/fimmu. 2021.720393. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34335634/.
  4. Maguire M, Maguire G. The role of microbiota, and probiotics and prebiotics in skin health. Arch Dermatol Res. [Internet] 2017 Aug [citado 2022 junho 14]; 309(6):411-421. doi: 10.1007/s00403-017-1750-3. Disponível em: https://pubmed.ncbi.nlm.nih.gov/28631091/.
  5. Lunjani N, Hlela C, O'Mahony L. Microbiome and skin biology. Curr Opin Allergy Clin Immunol. [Internet] 2019 Aug [citado 2022 junho 20]; 19(4):328-333. doi: 10.1097/ACI.0000000000000542. PMID: 31107258. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31107258/.
  6. Myers B, Brownstone N, Reddy V, Chan S, Thibodeaux Q, Truong A, Bhutani T, Chang HW, Liao W. The gut microbiome in psoriasis and psoriatic arthritis. Best Pract Res Clin Rheumatol. [Internet] 2019 Dec [citado 2022 junho 17]; 33(6):101494. doi: 10.1016/j.berh.2020.101494. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32360228/.
  7. Boyajian JL, Ghebretatios M, Schaly S, Islam P, Prakash S. Microbiome and Human Aging: Probiotic and Prebiotic Potentials in Longevity, Skin Health and Cellular Senescence. Nutrients. [Internet] 2021 Dec 18 [citado 2022 junho 18]; 13(12):4550. doi: 10.3390/nu13124550. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34960102/.
  8. Karimkhani C, Dellavalle RP, Coffeng LE, Flohr C, Hay RJ, Langan SM, Nsoesie EO, Ferrari AJ, Erskine HE, Silverberg JI, Vos T, Naghavi M. Global Skin Disease Morbidity and Mortality: An Update From the Global Burden of Disease Study 2013. JAMA Dermatol. [Internet] 2017, May 1 [citado 2022 junho 19]; 153(5):406-412. doi: 10.1001/jamadermatol.2016.5538. Disponível em: https://pubmed.ncbi.nlm.nih.gov/28249066/.
  9. Zeeuwen PL, Kleerebezem M, Timmerman HM, Schalkwijk J. Microbiome and skin diseases. Curr Opin Allergy Clin Immunol. [Internet] 2013, Oct [citado 2022 junho 21]; 13(5):514-20. doi: 10.1097/ACI.0b013e328364ebeb. Disponível em: https://pubmed.ncbi.nlm.nih.gov/23974680/.
  10. Green N, Miller T, Suskind D, Lee D. A Review of Dietary Therapy for IBD and a Vision for the Future. Nutrients. [Internet] 2019, Apr 26 [citado 2022 junho 22]; 11(5). pii: E947. doi: 10.3390/nu11050947. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31035465/.
  11. Hogenová HT, Zákostelská ZJ, Petanová J, Kverka M. Microbiota, immunity and immunologically-mediated diseases. Vnitr Lek. Winter; [Internet] 2019, [citado 2022 junho 16]; 65(2):98-107. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30909699/.
  12. Kiousi DE, Karapetsas A, Karolidou K, Panayiotidis MI, Pappa A, Galanis A. Probiotics in Extraintestinal Diseases: Current Trends and New Directions. Nutrients. [Internet] 2019, Apr 5 [citado 2022 junho 23]; 11(4). pii: E788. doi: 10.3390/nu11040788. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30959761/.
  13. Bonamonte D, Filoni A, Vestita M, Romita P, Foti C, Angelini G. The Role of the Environmental Risk Factors in the Pathogenesis and Clinical Outcome of Atopic Dermatitis. Biomed Res Int. [Internet] Apr 21 [citado 2022 junho 24]; 2019:2450605. doi: 10.1155/2019/2450605. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31119157/.
  14. O'Neill CA, Monteleone G, Mclaughlin JT, Paus R. The gut-skin axis in health and disease: A paradigm with therapeutic implications. Bioessays. [Internet] 2016, Nov [citado 2022 junho 15]; 38(11):1167-1176. doi: 10.1002/bies.201600008. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27554239/.
  15. Clark AK, Haas KN, Sivamani RK. Edible Plants and Their Influence on the Gut Microbiome and Acne. Int J Mol Sci. [Internet] 2017, May 17 [citado 2022 junho 21]; 18(5). pii: E1070. doi: 10.3390/ijms18051070. Disponível em: https://pubmed.ncbi.nlm.nih.gov/28513546/.
  16. Witte M, Thaçi D. Psoriasis and the microbiome. Hautarzt. [Internet] 2017, Jun [citado 2022 junho 14]; 70(6):416-421. doi: 10.1007/s00105-019-4415-7. Disponível em: https://pubmed.ncbi.nlm.nih.gov/?term=Psoriasis+and+the+microbiome.
  17. Visser MJE, Kell DB, Pretorius E. Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris. Front Cell Infect Microbiol. [Internet] 2019, Feb 4 [citado 2022 junho 22]; 9:7. doi: 10.3389/fcimb.2019.00007. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30778377/.
  18. Algazina T, Yermekbayeva B, Batpenova G, Kushugulova A. Features of microbiota in psoriatic disease: from skin and gut perspectives (review). Georgian Med News. [Internet] 2019, Feb [citado 2022 junho 18]; (287):98-104. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30958298/.
  19. Denton CP, Murray C. Cause or effect? Interpreting emerging evidence for dysbiosis in systemic sclerosis. Arthritis Res Ther. [Internet] 2019, Mar 27 [citado 2022 junho 12]; 21(1):81. doi: 10.1186/s13075-019-1872-4. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30917857/.
  20. Sanders ME, Merenstein DJ, Reid G, Gibson GR, Rastall RA. Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nat Rev Gastroenterol Hepatol. [Internet] 2019, Oct [citado 2022 junho 22]; 16(10):605-616. doi: 10.1038/s41575-019-0173-3. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31296969/.

How to Cite

Lima, J. B. de O. (2023). Major approaches to the skin-gut microbiota axis under the light of the nutrology of probiotics and prebiotics: a systematic review. International Journal of Nutrology, 16(2). https://doi.org/10.54448/ijn23222