Abstract
Introduction: In the scenario of nutritional impacts on quality of life, genetic, environmental, and lifestyle factors can determine the life expectancy of human beings. Nutrition is a key component that affects our health, and several studies show that nutrition also has the potential to increase life expectancy. Objective: A systematic review was developed to describe immune strengthening and healthy longevity in light of nutrology and lifestyle changes. Methods: The PRISMA Platform systematic review rules were followed. The research was carried out from March to April 2025 in the Scopus, Embase, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 134 articles were found, and 36 articles were evaluated, and 09 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 28 studies with a high risk of bias and 32 studies that did not meet GRADE. Most studies showed homogeneity in their results, with X2=82.7%>50%. It was concluded that nutrients and natural substances from human physiology and biochemistry such as melatonin and coenzyme Q10 control the functions of the immune system. Many metabolic or chronic diseases have been implicated in poor diet and lifestyle. Improving diet quality is associated with reduced all-cause mortality, considering that multivitamin and multimineral supplements can improve life expectancy. Overall well-being is improved when sedentary but sufficiently physically active adults reduce the time spent sedentary and increase physical activity levels. The results of the pandemic indicate there have been a variety of lifestyle changes, physical inactivity, and psychological problems.