Abstract
Introduction: Cervical cancer is the second leading cause of death among women of childbearing age worldwide. In 2020, an incidence of 604,000 and 342,000 deaths were estimated. Possible primary preventive strategies include diet and dietary supplements. Objective: This was to conduct a systematic review to clarify the main scientific evidence from clinical studies on the prevention and treatment of cervical cancer through nutritional triggers and nutrology. Methods: The systematic review rules of the PRISMA Platform were followed. The search was conducted from February to May 2025 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 81 articles were found. A total of 20 articles were evaluated in full and 15 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 31 studies with a high risk of bias and 24 studies that did not meet GRADE and AMSTAR-2. Most studies showed homogeneity in their results, with X2=89.8%>50%. It was concluded that a diet rich in plant-based nutrients may be important in reducing the risk of cervical cancer. Adherence to the Mediterranean diet reduces the risk of cervical cancer by 60%. Changes in dietary habits may contribute to preventing the onset of cervical cancer by 30% to 40%. The consumption of sugary drinks is associated with type II endometrial cancer. The consumption of fruits and vegetables reduces the risk of cervical cancer. Vitamin D may exert beneficial actions in the early stages of cervical cancer, preventing its onset and progression. Lactobacillus strains isolated from human breast milk may be considered a topical drug with a potential therapeutic index due to their efficacy against cervical cancer cells.