Abstract
Introduction: Metabolism encompasses the interactions between diet, the microbiome, and cellular enzymatic processes that generate the chemical pathways necessary to sustain life. Epigenetic and nutritional mechanisms are of paramount importance, as approximately 80.0% of patients lose weight during inflammatory bowel diseases (IBD). Objective: It was to develop a systematic review of the main clinical studies on the impact of nutritional treatment on inflammatory bowel diseases. Methods: The PRISMA Platform systematic review rules were followed. The research was carried out from March to April 2025 in the Scopus, Embase, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 132 articles were found, and 20 articles were evaluated in full and 17 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 14 studies with a high risk of bias and 20 studies that did not meet GRADE and AMSTAR-2. Most studies showed homogeneity in their results, with X2=78.4%>50%. It was concluded that important randomized controlled clinical studies in recent years have highlighted the important role of diet modulation in the control and even remission of inflammatory bowel diseases. There was a reduction in persistent intestinal symptoms, balance of the gut microbiota, reduction of inflammatory markers, and improvement in quality of life.