Skip to main content Skip to main navigation menu Skip to site footer
Articles
Published: 11-05-2021

Gluten intolerance and hashimoto thyroiditis: an integrated review

Etianne Bartz Institute, Fortaleza, Ceará, Brazil
Etianne Bartz Institute, Fortaleza, Ceará, Brazil
Autoimmune diseases Intestinal permeability Food allergies Food intolerances Gluten intolerance Hypothyroidism Hashimoto's thyroiditis

Abstract

The advent of agriculture about 10,000 years ago enabled the massive and widespread use of grains containing gluten in food. Thus, it represented an evolutionary challenge that has not yet been overcome and created the conditions for the development of diseases related to exposure to gluten in humans. The so-called hypersensitivity involves any abnormal reaction resulting from eating a particular food. We are now looking at another interesting phenomenon that is causing great confusion among healthcare professionals. The number of individuals embracing a gluten-free diet appears far greater than the predicted number of celiac patients, fueling a global gluten-free product market approaching $2.5 billion (US) in global sales in 2010. This trend is supported by the notion that, along with celiac disease, other conditions related to gluten intake have emerged as health concerns. Hashimoto's Thyroiditis is an autoimmune disease and the most common cause of hypothyroidism in our environment. It occurs with high familial aggregation and there seems to be a clear genetic predisposition, with an apparent autosomal dominant inheritance of autoantibodies in affected individuals. Food intolerance and allergies and intestinal permeability can accompany hypothyroidism. Food (food intolerance and allergies), bacteria, viruses, chemicals, excess bacterial growth in the intestine, intestinal permeability, and contaminants are the main culprits for the autoimmune thyroid disease – Hashimoto's thyroiditis.

Metrics

Metrics Loading ...

References

  1. Pobłocki J, Pańka T, Szczuko M, Telesiński A, Syrenicz A. Whether a Gluten-Free Diet Should Be Recommended in Chronic Autoimmune Thyroiditis or Not?-A 12-Month Follow-Up. J Clin Med. 2021 Jul 22;10(15):3240. doi: 10.3390/jcm10153240. PMID: 34362024; PMCID: PMC8347530.
  2. Panchangam RB, Kota SK, Mayilvaganan S, Kuravi BG. What is the impact of thyroidectomy on autoimmune features associated with Hashimoto's thyroiditis?-Institutional experience. Niger J Clin Pract. 2021 Jun;24(6):905-910. doi: 10.4103/njcp.njcp_426_20. PMID: 34121740.
  3. Ihnatowicz P, Drywień M, Wątor P, Wojsiat J. The importance of nutritional factors and dietary management of Hashimoto's thyroiditis. Ann Agric Environ Med. 2020 Jun 19;27(2):184-193. doi: 10.26444/aaem/112331. Epub 2019 Oct 2. PMID: 32588591.
  4. Krysiak R, Szkróbka W, Okopień B. The Effect of Gluten-Free Diet on Thyroid Autoimmunity in Drug-Naïve Women with Hashimoto's Thyroiditis: A Pilot Study. Exp Clin Endocrinol Diabetes. 2019 Jul;127(7):417-422. doi: 10.1055/a-0653-7108. Epub 2018 Jul 30. PMID: 30060266.
  5. Balaceanu A, Omer S, Stirban R, Zara O, Dina I. Hyposplenism, Hashimoto's Autoimmune Thyroiditis and Overlap Syndrome (Celiac Disease and Autoimmune Hepatitis Type 1). Am J Med Sci. 2020 Sep;360(3):293-299. doi: 10.1016/j.amjms.2020.04.022. Epub 2020 Apr 25. PMID: 32563569.
  6. Besser GM, Thorner MO. Comprehensive Clinical Endocrinology, 3rd ed. Philadelphia: Mosby, Elsevier Science, 2002.
  7. Burger AG. Environment and thyroid function. J. Clin. Endocrinol. Metab., 89:1526, 2004.
  8. Camargo RY, Tomimori EK, Neves SC, Rubio IG, Galrão AL, Knobel M et al. Thyroid and the environment: exposure to excessive nutritional iodine increases the prevalence of thyroid disorders in São Paulo, Brazil. Eur J Endocrinol. 2008;159:293-9.
  9. Cooper DS. Hyperthyroidism. Lancet 362:459,2003.
  10. Boucai L. Hollowell, J.G.; Surks, M.I. An approach for development of age-, gender-, and ethnicity-specific thyrotropin reference limits. Thyroid. 2011;21:5-11.
  11. Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado Thyroid Disease Prevalence Study. Arch Int Med. 2000;160:526-34.
  12. De La Vieja A, Dohan O et al: Molecular analysis of the sodium/iodide symporter: impact on thyroid and extrathyroid pathophysiology. Physiol Rev 80:1083, 2000.
  13. Dayan CM. Interpretation of thyroid function tests. Lancet 357:619, 2001.
  14. Dohan O, De La Vieja A, Paroder V et al. The Sodium/Iodide Symporter (NIS): characterization, regulation, and medical significance. Endocr Rev 24:48, 2003.
  15. Drum R. Environmental Origins of Thyroid Disease – Part 1. Botanical and Natural Treatments for Thyroid Dysfunction. Disponível em: www.ryandrum.com.
  16. Glinoer D. The systematic screening and management of hypothyroidism and hyperthyroidism during pregnancy. Trends Endocrinol Metab. 1998;9(10):403-11.
  17. Huber G, Staub JJ, Meier C, Mitrache C, Guglielmetti M, Huber P et al. Prospective study of the spontaneous course of subclinical hypothyroidism: prognostic value of thyrotropin, thyroid reserve, and thyroid antibodies. J Clin Endocrinol Metab. 2002;87(7):3221-6.
  18. Ladenson PW, Singer PA, Ain KB, Bagchi N, Bigos ST, Levy EG et al. American Thyroid Association guidelines for detection of thyroid dysfunction. Arch Intern Med. 2000;160(11):1573-5. Erratum in: Arch Intern Med 2001;161(2):284. Comment in:Arch Intern Med. 2001; 161(1):130.
  19. Larsen, P.R.; Kronenberg, H.M.; Melmed, S.; Polonsky, K.S.: Williams Textbook of Endocrinology, 10th ed. Philadelphia: WB Saunders Co, 2003.
  20. Leonard Wartofsky and Kenneth D. Burman Alterations in Thyroid Function in Patients with Systemic Illness: The “Euthyroid Sick Syndrome” Endocrine Rewiews July 01, 2013.
  21. Marino M.; Mccluskey RT. Role of thyroglobulin endocytic pathways in the control of thyroid hormone release. Am J Physiol Cell Physiol 279:C1295, 2000.
  22. O’Reilly DS. Thyroid function tests – time for a reassessment. BMJ 320:1332, 2000.
  23. Pearce EN, Farwell AP, Braverman LE. Thyroiditis. N Engl J Med 348:2646, 2003.
  24. Roberts CG, Ladenson PW. Hypothyroidism. Lancet 363:793, 2004.
  25. Romaldini JH, Sgarbi JA, Farah CS. Disfunções Mínimas da Tiróide: Hipotiroidismo Subclínico e Hipertiroidismo Subclínico. Arq Bras Endocrinol Metab vol 48 no 1 Fevereiro 2004.
  26. Sgarbi JA, Matsumura LK, Kasamatsu TS, Ferreira SR, Maciel RM. Subclinical thyroid dysfunctions are independent risk factors for mortality in a 7.5- year follow-up: the Japanese-Brazilian thyroid study. Eur J Endocrinol. 2010;162:569-77.
  27. Sgarbi JA, Teixeira PFS, Maciel LMZ, Mazeto GMFS, Vaisman M, Montenegro RM, Ward LS. Consenso brasileiro para a abordagem clínica e tratamento do hipotireoidismo subclínico em adultos: recomendações do Departamento de Tireoide da Sociedade Brasileira de Endocrinologia e Metabologia. Arq Bras Endocrinol Metab. 2013;57/3.
  28. Sheppard M. The Thyroid: Then and Now. The Endocrinologist. The Magazine of the Society for Endocrinology. 18:19. Spring, 2015.
  29. Sichieri R, Baima J, Marante T, DE Vasconcellos MT, Moura AS, Vaisman M. Low prevalence of hypothyroidism among black and Mulatto people in a population-based study of Brazilian women. Clin Endocrinol (Oxf). 2007;66:803-7.
  30. Silva GAR, Costa TB. Hipotireoidismo subclínico: uma revisão para o médico clínico. Rev Bras Clin Med. São Paulo, 2013 jul-set;11(3):289-95.
  31. Silva JE. The thermogenic effect of thyroid hormone and its clinical implications. Ann Intern Med 139:205, 2003.
  32. Simonsick EM, Newman AB, Ferrucci L, Satterfield S, Harris TB, Rodondi N et al. Subclinical hypothyroidism and functional mobility in older adults. Arch Intern Med. 2009;169(21):2011-7. Comment in: Arch Intern Med. 2009;169(21):1949-51.
  33. Stassi G, De Maria R. Autoimmune thyroid disease: new models of cell death in autoimmunity. Nat Rev Immunol 2:195, 2002.
  34. Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH et al. Subclinical thyroid disease. Scientific review and guidelines for diagnosis and management. JAMA. 2004;291(2):228-38. Comment in: JAMA. 2005;293(9):1059-60; author reply 1060. JAMA. 2004;292(21):2651-4. JAMA. 2004; 291(13):1562; author reply 1562-3. JAMA. 2004 Dec 1; 292(21):2651-4. JAMA. 2004 Dec 1; 292(21):2651-4. JAMA. 2004 Dec 1; 292(21):2651-4.
  35. Szkudlinski MW, Fremont V, Ronin C, Weintraub BD. Thyroid stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships. Physiol Rev 82:473, 2002.
  36. Tomer Y. Davies TF. Searching for the autoimmune thyroid disease susceptibility genes: from gene mapping to gene function. Endocr Rev 24:694, 2003.
  37. Vaidya B, Kendall-Taylor P, Pearce SH. The genetics of autoimmune thyroid disease. J Clin Endocrinol Metab 87:5385, 2002.
  38. Vasudevan N, Ogawa S, Pfaff D. Estrogen and thyroid hormone receptor interactions: physiological flexibility by molecular specificity. Physiol Rev 82:923, 2002.
  39. Yen PM. Physiological and molecular basis of thyroid hormone action. Physiol Rev 81:1097, 2001.
  40. Zhang J, Lazar MA. The mechanism of action of thyroid hormones. Annu Rev Physio 62:439, 2000.

How to Cite

Araújo, E. A., & Kerkhoff, S. P. (2021). Gluten intolerance and hashimoto thyroiditis: an integrated review. International Journal of Nutrology, 14(3). https://doi.org/10.54448/ijn2134