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International Journal of Nutrology
Articles
DOI: 10.1055/s-0040-1705069
Submitted: 02-05-2022
Published: 02-06-2022

Interface da má absorção da frutose e depressão: revisão sistemática da literatura

Curso de Medicina da UNIFENAS-BH
Curso de Medicina da UNIFENAS-BH
Curso de Medicina da UNIFENAS-BH
Curso de Medicina da UNIFENAS-BH
Curso de Medicina da UNIFENAS-BH
Professora do Curso de Medicina da UNIFENAS-BH
Professora do Curso de Medicina da UNIFENAS - BH /Universidade Federal de Minas Gerais (UFMG)
Fructose Intolerance Fructose Depression

Abstract

The present study aims to clarify whether patients with poorly absorption of fructose are more susceptible to develop depression. It is a systematic review of literature using the descriptors of health, in BVS Salud and Medline database. Inclusion criteria: studies with patients with or without fructose malabsorption, and with or without depressive symptoms, in all age, groups of both sexes and animal studies. In English, Spanish and Portuguese. Exclusion criteria: studies whose focus was not the fructose malabsorption affecting directly or indirectly in the emergence of depression. Nine articles were recovered, published in English between 1998 and 2014, two of them are reviews, one cross sectional study, five cohort and one clinical trial. The methodological quality was evaluated by the journal´s impact factor where the article was published; in addition to analyzing the quality of each by the CASP and Strobe, evaluated by EQUATOR. One positive relation between fructose malabsorption and depression was found in eight studies except one. The relation between fructose malabsorption and depression is hardly implemented in clinical / gastroenterological practice; so many cases are not being diagnosed. Nowadays, the prevalence of depression is high and the etiology is multifactorial. This is the first national study that correlates systematically the fructose malabsorption and depression. New studies are needed for the diagnosis and therapy.

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References

  1. Perito MES, Fortunato JJ. Marcadores Biológicos da Depressão: uma revisão sobre a expressão de fatores neurotróficos. Revista Neurociências 2012;20(4):597-603.
  2. Bahls SC. Depression in childhood and adolescence: clinical features. Jornal de Pediatria 2002;78(5):359-66.
  3. Joca SRL , Padovan CM , Guimarães FS. Estresse, depressão e hipocampo. Revista Brasileira de Psiquiatria 2003;25(2):46-51.
  4. Ledochowski M, Widner B, Bair H, Probst T, Fuchs D. Fructose- and Sorbitol-reduced Diet Improves Mood and Gastrointestinal Disturbances in Fructose Malabsorbers. Scand J Gastroenterol 2000;35(10):1048-53.
  5. Varea V, Carp JM, Puig C, Alda JA, Camacho E, Ormazabal A et al. Malabsorption of Carbohydrates and Depression in Children and Adolescents. J Pediatr Gastroenterol Nutr 2005;40(5):561-65.
  6. Ledochowski M, Widner B, Murr C, Sperner-Unterweger B, Fuchs D. Fructose malabsorption is associated with decreased plasma tryptophan. Scand J Gastroenterol 2001;36(4):367-71.
  7. Hanover LM, White JS. Manufacturing composition, and applications of fructose. Am J Clin Nutr 1993;58(5):724-32.
  8. Hill A, Crowe S, Brice R, Burls A, Bradley P, Alabed S et al. Critical Appraisal Skills Programme (CASP). Oxford. Disponível em: <http://media.wix.com/ugd/dded87_a02ff2e3445f4952992d5a96ca562576.pdf>. Acesso em: 14. mar. 2015.
  9. Christen MC, Altman DG, Egger M, Gøtzsche PC, Pocock SJ, Vandenbroucke JP et al. Strengthening the Reporting of Observational studies in Epidemiology (STROBE). Switzerland. Disponível em: <http://www.strobestate-ment.org/fileadmin/Strobe/uploads/checklists/STROBE_checklist_v4_combined.pdf>. Acesso em: 15. mar. 2015.
  10. Altman D, Groves T, Marušić A, Moher D, Ravaud P, Simera I. Enhancing the Quality and Transparency of Health Research (EQUATOR). Oxford. Disponível em: <http://www.equator-network.org>. Acesso em: 14. mar. 2015.
  11. Barreiros RC, Bossolan G, Trindade CEP. Frutose em humanos: efeitos metabólicos, utilização clínica e erros inatos associados.Rev Nutr 2005;18(3):377-89.
  12. Jones HF, Butler RN, Brooks DA. Intestinal fructose transport and malabsorption in humans. Am J Physiol Gastrointest Liver Physiol 2011;300(2):G202-G06.
  13. Gibson PR, Newnham E, Barrett JS , Shepherd SJ, Muir JG. Review article: fructose malabsorption and the bigger picture. Aliment Pharmacol Ther 2007;25(4):349-63.
  14. Born P. Carbohydrate malabsorption in patients with non-specific abdominal complaints. World J Gastroenterol 2007;13(43):5687-91.
  15. Latulippe ME, Skoog SM. Fructose Malabsorption and Intolerance: Effects of Fructose with and without Simultaneous Glucose Ingestion. Crit Rev Food Sci Nutr 201;51(7):583-92.
  16. Gaino NM, Silva MV. Consumo de frutose e impacto na saúde humana. Segr Alim Nutr 2011;18(2):88-98.
  17. Fernandez-Banhares F. Reliability of symptom analysis during carbohydrate hydrogen-breath tests. Curr Opin Clin Nutr Metab Care 2012;15(5):494-98.
  18. Baker RM, Shan MJ, Sclafani A, Bodnar RJ. Dopamine D1 and D2 antagonists reducethe acquisition and expressionista of flavor preferences conditioned bh fructose in rats. Pharmacol Biochem Behav 2003;75(1):55-65.
  19. Ledochowski M; Sperner-Unterweger B; Widner B; Fuchs D. Fructose malabsorption is associated with early signs of mental depression. Eur J Med Res 1998;3(6):295-98.
  20. Ledochowski M, Widner B, Sperner-Unterweger B, Propst T, Vogel W, Fuchs D. Carbohydrate malabsorption syndromes and early signs of mental depression in females. Dig Dis Sci 2000;45(7):1255-59.
  21. Simren M, Stotzer PO. Use and abuse of hydrogen breath tests. Gut 2006;55(3):297-303.
  22. Melchior C, Gourcerol G, De’chelotte P, Leroi AM, Ducrotte P. Symptomatic fructose malabsorption in irritable bowel syndrome: A prospective study. United European Gastroenterol J 2014;2(2):131-137.

How to Cite

Santos Júnior, J. R. dos, Cecília, N. C. S., Matheus, N. A., Cançado, T. S. B., Rodrigues, T. F., Andrade, V. L. Ângelo, & Araújo L. A. de. (2022). Interface da má absorção da frutose e depressão: revisão sistemática da literatura. International Journal of Nutrology, 8(2), 30–38. https://doi.org/10.1055/s-0040-1705069