Skip to main content Skip to main navigation menu Skip to site footer
International Journal of Nutrology
Articles
DOI: 10.1055/s-0040-1705273
Submitted: 02-06-2022
Published: 02-06-2022

É Possível Evitar a Recuperação do Peso após o Emagrecimento?

Sociedade Brasileira de Endocrinologia Regional Sul
Obesity Treatment Weight regain

Abstract

Obesity is a chronic disorder with a progressive and relapsing profile, and it has reached epidemic global proportions. It is a preventable and treatable cause of increased early mortality, however, in most of cases, it reaches only transitory success. When obese people lose weight, orexigen hormones increase and sacietogen ones decrease, causing a persistent increase in hunger and a decrease in body energy expenditure. In a obesogenic environment, this metabolic imbalance causes obesity relapse. The obesity treatment must focus in hyperproteic diets, intensive and frequent exercise and a combination of drugs that counteract the compensatory mechanisms present in who have lost weight.

Metrics

Metrics Loading ...

References

  1. World Health Organization. Obesity and Overwheight. Fact Sheet 311, 2015.
  2. Ministério da Saúde. Vigilância de fatores de risco e proteção para doenças crônicas por inquérito telefônico. Vigitel Brasil 2014.
  3. Ministério da Saúde. Estratégias para o cuidado da pessoa com doença crônica. Obesidade. Cadernos de atenção básica, 38. Ministério da saúde, Brasil, 2014.
  4. Kraschnewski JL, Boan J, Esposito J, Sherwood NE, Lehman EB, Kephart DK, Sciamanna CN. Long term weight loss maintenance in the United States. Int J Obes (Lond) 2010; 34: 1644–1654.
  5. Weiss EC, Galuska DA, Kettel Khan L, Gillespie C, Serdula MK. Weight regain in U.S. adults who experienced substantial weight loss, 1999–2002. Am J Prev Med 2007; 33: 34–40.
  6. Guyenet SJ, Schwartz MW. Clinical review: Regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity. J. Clin. Endocrinol. Metab. 2012; 97: 745–755.
  7. Begg DP, Woods SC. The endocrinology of food intake. Nat. Rev. Endocrinol. 2013; 9: 584–597.
  8. Thaler JP, Guyenet SJ, Dorfman MD, Wisse BE, Schwartz MW. Hypothalamic Inflammation: Marker or Mechanism of Obesity Pathogenesis? Diabetes 2013; 62: 2629-2634.
  9. Velloso LA, Schwartz LW. Altered hypothalamic function in diet-induced obesity J Obes (Lond). 2011 35(12): 1455–1465.
  10. Thaler JP, Yi CX, Schur EA ,Guyenet SJ, Hwang BH, Dietrich MO, Zhao T et al. Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest. 2012; 122(1): 153–162.
  11. MacLean PS, Bergouignan A, Cornier MA, Jackman MR. Biology’s response to dieting: the impetus for weight regain Am J Physiol Regul Integr Comp Physiol. 2011; 301(3): R581–R600.
  12. Sumithran P, Prendergast LA, Delbridge E, Purcell K, Shulkes A, Kriketos A, Proietto J. Long-Term Persistence of Hormonal Adaptations to Weight Loss. N Engl J Med 2011;365:1597-604.
  13. Rosenbaum M, Hirsch J, Gallagher, Leibel RL. Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight. Am J Clin Nutr 2008;88:906 –12.
  14. Ochner CN, Tsai AG, Kushner RF, Wadden TA. Treating obesity seriously: when recommendations for lifestyle change confront biological adaptations. Lancet Diabetes Endocrinol 2015; 3(4): 227-304.
  15. MacLean OS, Wing RR, Davidson T, Epstein L, Goodpaster B, Hall KD, Levin BE, et AL. NIH Working Group Report: Innovative Research to Improve Maintenance of Weight Loss. Obesity 2015;23(1): 7-15.
  16. McGuire MT, Wing RR, Klem ML, Hillf JO. Behavioral Strategies of Individuals Who Have Maintained Long-Term Weight Losses. Obesity Research 1999; 7 (4): 334-341.
  17. Butryn ML, Clark VL, Coletta MC. Behavioral approaches to the treatment of obesity. In: Akabas SR, Lederman SA, Moore BJ, editors. Textbook of Obesity: Biological, Psychological and Cultural Influences. John Wiley & Sons, 2011: 253-272.
  18. Wycherley TP, Moran LJ, Clifton PM, Noakes M, Brinkworth GD. Effects of energy-restricted high-protein, low-fat compared with standard-protein, low-fat diets: a meta-analysis of randomized controlled trials Am J Clin Nutr 2012;96:1281–98.
  19. Johansson K, Neovius M, Hemmingsson E. Effects of anti-obesity drugs, diet, and exercise on weight-loss maintenance after a very-low-calorie diet or low-calorie diet:a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr 2014;99:14–23.
  20. Krause WA. Long-term weight loss with sibutramine: a randomized controlled trial. JAMA. 2001;286(11):1331-1339.
  21. James WP, Astrup A, Finer N, Hilsted J, Kopelman P, Rössner S, Saris WH, Van Gaal LF. Effect of sibutramine on weight maintenance after weight loss: a randomised trial. STORM Study Group. Sibutramine Trial of Obesity Reduction and Maintenance. Lancet. 2000;356(9248):2119-25.
  22. Astrup A Caterson I, Zelissen P, Guy-Grand B, Carruba M, Levy B, Sun X, Fitchet M. Topiramate: long-term maintenance of weight loss induced by a low-calorie diet in obese subjects. Obes Res. 2004; 12(10):1658-69.
  23. Davidson MH, Hauptman J, DiGirolamo M, Foreyt JP, Halsted CH, Heber D, Heimburger DC, Lucas CP, Robbins DC, Chung J, Heymsfield SB. Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomized controlled trial. JAMA. 1999 Jan 20;281(3):235-42.
  24. Wadden TA,Hollander P, Klein S, Niswender K, Woo V,Hale PM, Aronne L. Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: The SCALE Maintenance randomized study. Int J Obes. 2013; 37(11): 1443-51.
  25. Garvey WT, Ryan DH, Look M, Gadde KM, Allison DB, Peterson CA, Schwiers M, Day WW, Bowden CH. Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study. Am J Clin Nutr. 2012; 95(2):297-308.
  26. Yanovski SZ, Yanovski JA. Long-term Drug Treatment for Obesity: A Systematic and Clinical Review. JAMA. 2014; 311(1): 74–86.
  27. Hendricks EJ, Rothman RB, Greenway FL. How physician obesity specialists use drugs to treat obesity. Obesity (Silver Spring). 2009;17(9):1730-5.
  28. Hussain HT, Parker JL, Sharma AM. Clinical trial success rates of anti-obesity agents: the importance of combination therapies. Obesity reviews (2015) 16: 707–714.

How to Cite

Peccin, S. (2022). É Possível Evitar a Recuperação do Peso após o Emagrecimento?. International Journal of Nutrology, 9(1), 140–143. https://doi.org/10.1055/s-0040-1705273