Abstract
Introduction: The global dental implant market generated approximately 13 billion dollars in 2023, with an annual growth of 6%. It is prioritized that the nutritional status significantly influences the osseointegration process. Objective: It was to conduct a systematic review to discuss the nutritional importance of optimizing the dental implant osseointegration process. Methods: The PRISMA Platform systematic review rules were followed. The search was carried out from November 2024 to January 2025 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: 123 articles were found, 25 articles were evaluated in full and 22 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 27 studies with a high risk of bias and 32 studies that did not meet GRADE. Most studies did not show homogeneity in their results, with X2=81.2%>50%. It was concluded that a specific dietary regimen and micronutrients may play a key role in the different phases of dental implant osseointegration. Some micronutrient deficiencies increase oxidative stress and inflammation, in addition to affecting collagen structure and bone mineralization. However, data are lacking for many micronutrients that may modulate bone metabolism. There is evidence for the role of vitamin D as well as vitamin C supplementation in facilitating the success of dental implant surgery.