Abstract
This investigation examines how, among overweight adults, modest dietary lowering of the glycaemic index (GI) affects recognised molecular markers of epigenetic ageing. GI, the established framework for ranking foods according to their postprandial glucose effect, is increasingly understood as a dietary signal influencing underlying biological ageing processes. The central premise of the present work is that sustained low-GI intervention dampens the rate of epigenetic ageing—a contributor to biological and cognitive senescence—and thereby attenuates the onset of age-related morbidity. To evaluate this hypothesis, epigenetic ageing indicators, prominently including across-genome DNA methylation signatures, were ascertained at baseline and at the conclusion of a 12-week low-GI prescriptive programme. The analysis demonstrates pronounced modulation of epigenetic markers within the dietary intervention cohort in contrast to the control cohort, indicating that modulation of the glycaemic index in the diet may attenuate biological senescence. This manuscript elaborates the pathways by which a low-glycaemic-index dietary regime exerts epigenetic effects, therein suggesting that systemic nutritional alterations stand as a plausible strategy for the enhancement of healthspan. Concurrently, the data affirm the clinical utility of habitual low-glycaemic-index food consumption as a preventive measure against senescence-related morbidities. Recommended trajectories for continuing enquiry are outlined, prioritising prospective longitudinal cohorts and a more exhaustive dissection of the molecular mechanisms engaged.