Abstract
Introduction: With Brånemark's concept of osseointegration in 1960, dental implants have seen significant advancements, particularly in the structural and functional connection between bone and the implant surface. One of the main predictors influencing osseointegration is bone quality fostered by nutrients and the absence of periodontitis. Objective: This study aimed to analyze the clinical considerations of nutrients and supplements in the treatment of periodontitis for dental implant success. Methods: The systematic review rules of the PRISMA Platform were followed. The search was conducted from March to April 2026 in the Web of Science, Scopus, Embase, PubMed, Science Direct, SciELO, and Google Scholar databases. The quality of the studies was based on the GRADE instrument, and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: According to the GRADE instrument, most studies presented homogeneity in their results, with X2=83.5%>50%. A total of 101 articles were found and submitted for eligibility analysis, with 13 final studies selected to compose the results of this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 12 studies with a high risk of bias and 22 studies that did not meet GRADE and AMSTAR-2. It was concluded that probiotic and prebiotic nutraceuticals, polyunsaturated fatty acids, and vitamins A, B, C, D, and E are the most commonly used in dentistry. Evidence suggests a positive relationship between adequate vitamin D levels and early osseointegration of dental implants. Regarding marginal bone changes and peri-implant soft tissue outcomes, the findings were consistent but statistically heterogeneous, with several studies indicating greater bone loss, thinner gingival phenotypes, or a more pro-inflammatory peri-implant environment in the presence of vitamin D deficiency.