Abstract
This study was designed to evaluate the effect of clomiphene citrate [Clomid drug] on Albino Rat ovary. A total of thirty healthy rats at three months of age, weighing 200–250 g on average and having regular estrous cycles for four days were divided into two groups [each of 15 rats]. Control group was administered orally saline, treated group was administered orally Clomid drug at 50 mg/kg for a period 14 day. The animals were sacrificed at ovaries were removed. Histological section of treated group with clomid showed elevating in numbers of developing follicles underlying atretic changes such as denoted oocyte and dissociation of theca externa and theca interna layers from ovary stromal tissue with increased incidence of apoptosis and numbers of inflammatory cells. Ovary cortex consisted of many congestion spots, other sections showed ovarian tissue replaced by dense fibrous connective tissue that is slightly vascularized cytoplasm and pynotic cell nuclei In addition to karyorrhexis in ovary stroma tissue and degenerative cells. Depending on the results of this study, we can conclude that treating albino rats with clomid for 14 days at a concentration of 50 mg / kg can increase the number of follicles, which leads to stimulation of ovulation without clear histopathological changes.