Abstract
Introduction: Helicobacter pylori (H. pylori) is a common bacterial infection linked to gastritis, peptic ulcers, and gastric cancer. Dietary habits may influence the acquisition, progression, and symptoms of this infection. In Palestine, the prevalence of H.pylori and dietary patterns raise public health concerns. This study explores the association between dietary factors and H. pylori infection severity in Palestine. Objectives: To assess the relationship between specific dietary practices and the prevalence and severity of H. pylori infection in Palestinian patients, aiming to inform preventive strategies and dietary management protocols. Methods: A cross-sectional study was conducted between 2023 and 2024, involving 269 H. pylori patients. Participants completed an online semi-quantitative food frequency questionnaire (FFQ) shared via social media. The questionnaire collected data on demographics, infection status, dietary intake, lifestyle factors, and medical history. Statistical analyses included t-tests, Mann-Whitney U-tests, χ²-tests, and Fisher’s exact tests, with significance set at p ≤ 0.05. Ethical approval was obtained from the IRB of An-Najah National University, Palestine. Results: Significant associations were found between diet and H. pylori symptoms. Fast food consumption correlated with bloating and heartburn (p < 0.01). Low vegetable intake was linked to upper abdominal pain (p < 0.01). Energy drink consumption was associated with bloating and nausea (p < 0.01), and citrus intake with upper abdominal pain (p < 0.01). Conclusion: Certain dietary behaviors, including high fast food and low vegetable intake, may exacerbate H. pylori symptoms. Integrating dietary modifications into H. pylori treatment plans is recommended, especially in resource-limited settings.