Abstract
Introduction: Oxidative stress, altered antioxidant status, and serum trace elements are all linked to chronic asthma. Objective: The study involved determination the levels of some clinical markers in serum of patient with chronic asthma relative to healthy people aiming at clarifying the relation among these changes. Methods: Serum levels of malondialdehyde MDA, glutathione (GSH), vitamin C, uric acid, total protein, albumin, globulin and trace elements chromium Cr and selenium Se were measured in (200 asthma and 200 supposed healthy subjects) sex (100 male, 100 female). Results: Statistical data analysis revealed a significant elevation in the levels of malondialdehyde in serum of patients with chronic asthma relative to control group. The study also showed a signification decrease in glutathione, chromium, selenium in serum of patients in comparison to control groups for both sexes. On the other hand, signification decrease was observed in uric acid, vitamin C, total protein and albumin and no signification deferent in globulin in serum of patients with chronic asthma in comparison to control group and for both sexes. Conclusion: There was no effect of sex on the studied markers.
Graphical Abstract