Abstract
Introduction: Hypothyroidism is a widespread endocrine illness that has major effects on the body as a whole, especially on the regulation of blood vessels. When hypertension is also present, it makes endothelial dysfunction much worse. Objective: This study aimed to assess the Clinical and Nutrological Metabolic Parameters Influencing Vasodilation Mechanisms in the Initial Phases of Hypothyroidism and Hypertension. Methods: Tests were measured in addition to Prostaglandin E Synthase, Bradykinin, and Kallikrein levels using ELISA in early hypothyroidism and hypothyroidism with hypertension among 90 participants consisting of 35 hypothyroid participants, 35 hypothyroid participants with hypertension, and 20 controls attending the Endocrinology Department at Azadi Teaching Hospital from January to May 2025. Results: The hypothyroid group was dominated by females, 60.0%, while in controls the male sex was the majority, 65.0%. The hypertensive hypothyroidism group had the highest mean age of 47.1 ± 15.82 years. Obesity was significantly higher in hypothyroidism with hypertension, 54.29%. When compared to controls, thyroid hormone tests showed that both patient groups had significantly higher TSH and significantly lower T3 and T4 (p<0.05) when One way ANOVA applied. Vasodilatory markers were significantly lower in the patient groups. Prostaglandin E Synthase levels were much lower in hypothyroidism - 206.74 ng/mL and hypothyroidism with hypertension - 182.05 ng/ml compared to controls - 397.94 ng/mL. Conclusion: Bradykinin and Kallikrein also revealed significant declines, and the levels were lowest in hypertensive hypothyroidism. These findings indicate that early hypothyroidism, when combined with hypertension, is strongly associated with impaired vasodilatory signaling, thus suggesting an early evaluation of cardiovascular risk in thyroid disorders.